November 26, 2015
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Suprenza Side Effects Center

Medical Editor: Melissa Conrad Stöppler, MD

Suprenza is an orally disintegrating tablet (ODT) of phentermine hydrochloride. Phentermine hydrochloride is a sympathomimetic amine anorectic. Suprenza is indicated as a short-term (a few weeks) adjunct in a regimen of weight reduction based on exercise, behavioral modification, and caloric restriction in the management of exogenous obesity for patients with an initial body mass index ≥ 30 kg/m², or ≥ 27 kg/m² in the presence of other risk factors such as controlled hypertension, diabetes, or hyperlipidemia (high fat levels in the blood). Side effects of Suprenza include primary pulmonary hypertension, valvular heart disease, risk of dependence, and withdrawal effects. The safety and efficacy of combining Suprenza with antidepressants and other weight loss drugs and herbs has not been studied.

Dosage should be individualized to obtain an adequate response with the lowest effective dose. Consumption of alcohol should be avoided while taking Suprenza, as an adverse drug reaction may result. When tolerance to the effect of Suprenza develops, the recommended dose should not be exceeded in an attempt to increase the effect; rather, the drug should be discontinued. Suprenza is contraindicated during pregnancy because weight loss offers no potential benefit to a pregnant woman and may result in fetal harm. It is not known if Suprenza is excreted in human milk; however, other amphetamines are present in human milk. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Our Suprenza (phentermine hydrochloride) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Suprenza FDA Prescribing Information: Side Effects
(Adverse Reactions)


The following adverse reactions are described, or described in greater detail, in other sections:

The following adverse reactions to phentermine have been identified:


Primary pulmonary hypertension and/or regurgitant cardiac valvular disease, palpitation, tachycardia, elevation of blood pressure, ischemic events.

Central Nervous System

Overstimulation, restlessness, dizziness, insomnia, euphoria, dysphoria, tremor, headache, psychosis.


Dryness of the mouth, unpleasant taste, diarrhea, constipation, other gastrointestinal disturbances.




Impotence, changes in libido.

Read the entire FDA prescribing information for Suprenza (phentermine hydrochloride)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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