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SURFAXIN (lucinactant) Intratracheal Suspension is a sterile, non-pyrogenic pulmonary surfactant intended for intratracheal use only. It is a synthetic formulation consisting of phospholipids, a fatty acid, and sinapultide (KL4 peptide), a 21-amino acid hydrophobic synthetic peptide. The chemical names, structures, and empirical formulas of the 4 active components of SURFAXIN are:
Sinapultide (KL4 acetate)
Chemical Name: L-Lysyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-lysyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-lysyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-lysyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-lysine, acetate
Empirical Formula: C126H238N26O22 Molecular Weight: 2469.46
Chemical Name: 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
Empirical Formula: C40H80NO8P Molecular Weight: 734.06
Chemical Name: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, sodium salt
Empirical Formula: C40H76O10PNa Molecular Weight: 771.00
Chemical Name: Palmitic acid (hexadecanoic acid)
Empirical Formula: C16H32O2 Molecular Weight: 256.43
SURFAXIN is a white to off-white opaque gel-like suspension at 2° to 8°C (36° to 46°F), which becomes a free-flowing suspension upon warming for 15 minutes in a dry block heater set at 44°C (111°F). Each mL of SURFAXIN provides 30 mg phospholipids (22.50 mg DPPC and 7.50 mg POPG, Na), 4.05 mg PA, and 0.862 mg sinapultide in tromethamine and sodium chloride. Glacial acetic acid is used to adjust the pH of the buffer to 7.4 (range 7.0 to 8.0). SURFAXIN contains no preservatives.
Last reviewed on RxList: 3/16/2012
This monograph has been modified to include the generic and brand name in many instances.
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