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home > drugs a-z list > surmontil (trimipramine) drug center > surmontil (trimipramine) drug - clinical pharmacology
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Tricyclic Antidepressants (TCAs) »
What are tricyclic antidepressants, and how do they work?
Tricyclic antidepressants (TCAs) are a class of antidepressant medications that share a similar chemical structure and biological effects. Scientists believe that patients with depression may have an imbalance in neurotransmitters, chemicals that nerves make and use to communicate with other nerves. Tricyclic antidepressants increase levels of norepinephrine and serotonin, two neurotransmitters, and block the action of acetylcholine, another neurotransmitter. Scientists believe that by restoring the balance in these neurotransmitters in the brain that tricyclic antidepressants alleviate depression. In addition to relieving depression, tricyclic antidepressants also cause sedation and block the action of histamine.
For what conditions are tricyclic antidepressants used?
Tricyclic antidepressants are approved by the Food and Drug Administration (FDA) for treating ...
Surmontil
CLINICAL PHARMACOLOGY
Surmontil (trimipramine) is an antidepressant with an anxiety-reducing sedative component to its action. The mode of action of Surmontil (trimipramine) on the central nervous system is not known. However, unlike amphetamine-type compounds it does not act primarily by stimulation of the central nervous system. It does not act by inhibition of the monoamine oxidase system.
The single-dose pharmacokinetics of trimipramine were evaluated in a comparative study of 24 elderly subjects and 24 younger subjects; no clinically relevant differences were demonstrated based on age or gender.
Last reviewed on RxList: 9/5/2007
This monograph has been modified to include the generic and brand name in many instances.
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