"May 26, 2015 -- Cystic fibrosis has been a frightening fact of life for Paige Ellens and her mother, Sharla, since Paige was born 17 years ago.
This ongoing, life-threatening disease causes the lungs to fill up with thick and sticky mucus. "...
(siltuximab) for Injection
SYLVANT (siltuximab) is a human-mouse chimeric monoclonal antibody that binds human interleukin-6 (IL-6). SYLVANT is produced by Chinese hamster ovary cells.
SYLVANT is supplied as a sterile, white, preservative free, lyophilized powder in single-use vials.
Each SYLVANT 100 mg single-use vial contains 100 mg siltuximab, 3.7 mg L-histidine (from L-histidine and L-histidine monohydrochloride monohydrate), 0.8 mg polysorbate 80, and 169 mg sucrose.
Each SYLVANT 400 mg single-use vial contains 400 mg siltuximab, 14.9 mg L-histidine (from L-histidine and L-histidine monohydrochloride monohydrate), 3.2 mg polysorbate 80, and 677 mg sucrose.
Following reconstitution with Sterile Water for Injection, USP (per section 2.2), the resulting pH is approximately 5.2. The resulting solution contains 20 mg/Ml siltuximab to be administered by intravenous infusion following dilution [see DOSAGE AND ADMINISTRATION].
Last reviewed on RxList: 4/22/2016
This monograph has been modified to include the generic and brand name in many instances.
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