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In this Article

• What is fluoxetine and olanzapine (Symbyax)?
• What are the possible side effects of fluoxetine and olanzapine (Symbyax)?
• What is the most important information I should know about fluoxetine and olanzapine (Symbyax)?
• What should I discuss with my healthcare provider before taking fluoxetine and olanzapine (Symbyax)?
• How should I take fluoxetine and olanzapine (Symbyax)?
• What happens if I miss a dose (Symbyax)?
• What happens if I overdose (Symbyax)?
• What should I avoid while taking fluoxetine and olanzapine (Symbyax)?
• What other drugs will affect fluoxetine and olanzapine (Symbyax)?
• Where can I get more information?

What happens if I miss a dose (Symbyax)?

Take the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take extra medicine to make up the missed dose.

What happens if I overdose (Symbyax)?

Seek emergency medical attention if you think you have taken too much of this medication. Overdose symptoms may include nausea, vomiting, tremor, problems with speech or vision, seizure (convulsions), and coma.

What should I avoid while taking fluoxetine and olanzapine (Symbyax)?

Drink plenty of fluids, especially in hot weather and during exercise. It is easier to become dangerously overheated and dehydrated while you are taking fluoxetine and olanzapine.

Avoid drinking alcohol, which can increase some of the side effects of fluoxetine and olanzapine.

Fluoxetine and olanzapine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

What other drugs will affect fluoxetine and olanzapine (Symbyax)?

Talk to your doctor before taking any medicine for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), indomethacin, piroxicam (Feldene), nabumetone (Relafen), etodolac (Lodine), and others. Taking any of these drugs with fluoxetine and olanzapine may cause you to bruise or bleed easily.

Before using fluoxetine and olanzapine, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures or anxiety). They can add to sleepiness caused by fluoxetine and olanzapine.

The following drugs can interact with fluoxetine and olanzapine. Tell your doctor if you are using any of these:

• vinblastine (Velban);
• heart rhythm or blood pressure medication;
• tryptophan (sometimes called L-tryptophan);
• lithium, clozapine (Clozaril, Fazaclo), haloperidol (Haldol);
• phenytoin (Dilantin), carbamazepine (Carbatrol, Tegretol);
• a blood thinner such as warfarin (Coumadin);
• another form of fluoxetine or olanzapine such as Prozac, Prozac Weekly, Sarafem, or Zyprexa;
• theophylline (Theo-Dur, TheoBid, Uniphyl, Slo-Bid, Elixophyllin, and others);
• medicine to treat Parkinson's disease, such as bromocriptine (Parlodel), pergolide (Permax), pramipexole (Mirapex), ropinorole (Requip), or cabergoline (Cabaser);
• almotriptan (Axert), frovatriptan (Frova), sumatriptan (Imitrex), naratriptan (Amerge), rizatriptan (Maxalt), or zolmitriptan (Zomig); or
• any other antidepressants.

This list is not complete and there may be other drugs that can interact with fluoxetine and olanzapine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about fluoxetine and olanzapine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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