Symlin (Pramlintide Acetate Injection) Drug Information: Overdosage and Contraindications

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May 27, 2012

Symlin

Diabetes Treatment »

How is diabetes treated?

The major goal in treating diabetes is to minimize any elevation of blood sugar (glucose) without causing abnormally low levels of blood sugar. Type 1 diabetes is treated with insulin, exercise, and a diabetic diet. Type 2 diabetes is treated first with weight reduction, a diabetic diet, and exercise. When these measures fail to control the elevated blood sugars, oral medications are used. If oral medications are still insufficient, treatment with insulin is considered.

Adherence to a diabetic diet is an important aspect of controlling elevated blood sugar in patients with diabetes. The American Diabetes Association (ADA) has provided guidelines for a diabetic diet. The ADA diet is a balanced, nutritious diet that is low in fat, cholesterol, and simple sugars. The total daily calories are evenly divided into three meals. In the past two years, the ADA has lifted the absolute ban on simple sugars. Small amounts of si...

Read the Diabetes Treatment article »

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OVERDOSE

Single 10 mg doses of SYMLIN (pramlintide acetate injection) (83 times the maximum dose of 120 mcg) were administered to three healthy volunteers. Severe nausea was reported in all three individuals and was associated with vomiting, diarrhea, vasodilatation, and dizziness. No hypoglycemia was reported. SYMLIN (pramlintide acetate injection) has a short half-life and in the case of overdose, supportive measures are indicated.

CONTRAINDICATIONS

SYMLIN (pramlintide acetate injection) is contraindicated in patients with any of the following:

a known hypersensitivity to SYMLIN (pramlintide acetate injection) or any of its components, including metacresol;
a confirmed diagnosis of gastroparesis;
hypoglycemia unawareness.

Last reviewed on RxList: 4/9/2008
This monograph has been modified to include the generic and brand name in many instances.