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Single 10 mg doses of SYMLIN (83 times the maximum recommended dose of 120 mcg for patients with type 2 diabetes) were administered to 3 healthy volunteers. All 3 individuals reported severe nausea associated with vomiting, diarrhea, vasodilatation, and dizziness. No hypoglycemia was reported. Pramlintide has a short half-life (approximately 48 minutes in healthy individuals). Initiate supportive measures in the case of overdose.
SYMLIN is contraindicated in patients with any of the following:
- serious hypersensitivity reaction to SYMLIN or to any of its product components.
- hypoglycemia unawareness.
- confirmed gastroparesis.
Last reviewed on RxList: 7/14/2014
This monograph has been modified to include the generic and brand name in many instances.
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