May 24, 2017
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Symlin Patient Information Including Side Effects

Brand Names: Symlin, SymlinPen 120, SymlinPen 60

Generic Name: pramlintide (Pronunciation: PRAM lin tide)

What is pramlintide (Symlin)?

Pramlintide is a man-made form of a hormone that occurs naturally in the body. Pramlintide lowers blood sugar in three ways. It slows the rate that food moves from your stomach to your intestines, which keeps your blood sugar from rising too fast. Pramlintide also lowers the amount of glucose (sugar) your liver produces. Lastly, pramlintide triggers the feeling of fullness after meals to help control your appetite and decrease how much food you eat.

Pramlintide is used together with insulin to treat type 1 or type 2 diabetes.

Pramlintide may also be used for other purposes not listed in this medication guide.

What are the possible side effects of pramlintide (Symlin)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • severe nausea that lasts for 3 to 7 days; or
  • more frequent high blood sugar levels.

Less serious side effects may include:

  • runny or stuffy nose, sore throat, cough;
  • nausea, loss of appetite;
  • headache, tired feeling; or
  • joint pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the Symlin (pramlintide acetate injection) Side Effects Center for a complete guide to possible side effects

What is the most important information I should know about pramlintide (Symlin)?

Do not mix pramlintide and insulin together in the same syringe.

You will need to use a lower dose of insulin than you used before you started using pramlintide. Your doctor will determine your correct dose.

Call your doctor if you have severe nausea that lasts for several days. This may be a sign that your dose is too high.

If you skip a meal, do not take your dose of pramlintide. Wait until your next meal.

If you stop using pramlintide for a short time, you may need to restart the medication at a lower dose. Do not change your doses or medication schedule without your doctor's advice.

Take care not to let your blood sugar get too low, causing hypoglycemia. Severe hypoglycemia may occur within 3 hours after your pramlintide injection. Carry hard candy or glucose tablets with you in case you have low blood sugar. Be sure your family and close friends know how to help you in an emergency.

Side Effects Centers

Symlin - User Reviews

Symlin User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Symlin sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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