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Symmetrel

Last reviewed on RxList: 1/26/2017
Symmetrel Side Effects Center

Last reviewed on RxList 12/1/2016

Symmetrel (amantadine hydrochloride) is an anti-Parkinson and an antiviral drug prescribed to prevent or treat symptoms of infection caused by strains of influenza A virus. Symmetrel is also used in the treatment of Parkinson's Disease and similar conditions. Symmeterel is available in generic form. Common side effects of Symmetrel include:

  • nausea,
  • stomach upset,
  • diarrhea,
  • constipation,
  • loss of appetite,
  • dizziness,
  • drowsiness,
  • headache,
  • sleep problems (insomnia),
  • strange dreams,
  • nervous feeling,
  • dry mouth,
  • dry nose,
  • blurred vision, or
  • loss of balance or coordination.

Tell your doctor if you have unlikely but serious side effects of Symmetrel including:

  • purplish-red blotchy spots on the skin,
  • swelling of the ankles or feet,
  • difficulty urinating, or
  • vision changes.

The adult daily dosage of Symmeterel is 200 mg per day, taken orally. The dose for patients over 65 is 100 mg per day, and the pediatric dose is calculated based on the child's weight. Doses may be modified based on your medical condition and your response to therapy. Do not take Symmeterel if you have taken flu vaccine inhaled through the nose, as serious adverse reactions may occur. Symmetrel may interact with atropine, dicyclomine, glycopyrrolate, hyoscyamine, mepenzolate, methscopolamine, propantheline, scopolamine, quinine, quinidine, diuretics (water pills), or phenothiazines. Tell your doctor all medications and supplements you use. Symmeterel should not be used during pregnancy unless needed as it can cause heart defects in the fetus. It is not recommended for women who are nursing as it can pass into breast milk. Do not suddenly stop taking Symmeteral as symptoms or side effects may worsen.

Our Symmetrel Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Symmetrel Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • feeling short of breath, even with mild exertion;
  • swelling, rapid weight gain;
  • feeling depressed, agitated, or aggressive;
  • behavior changes, hallucinations, thoughts of hurting yourself;
  • urinating less than usual or not at all;
  • high fever, stiff muscles, confusion, sweating, fast or uneven heartbeats, rapid breathing, feeling like you might pass out;
  • restless muscle movements in your eyes, tongue, jaw, or neck; or
  • tremor (uncontrolled shaking).

Less serious side effects may include:

  • dizziness, drowsiness, headache;
  • sleep problems (insomnia), strange dreams;
  • feeling nervous;
  • nausea, diarrhea, constipation, loss of appetite;
  • dry mouth, dry nose; or
  • loss of balance or coordination.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Symmetrel (Amantadine Hydrochloride)

Symmetrel Professional Information

SIDE EFFECTS

The adverse reactions reported most frequently at the recommended dose of SYMMETREL (amantadine hydrochloride) (5-10%) are: nausea, dizziness (lightheadedness), and insomnia.

Less frequently (1-5%) reported adverse reactions are: depression, anxiety and irritability, hallucinations, confusion, anorexia, dry mouth, constipation, ataxia, livedo reticularis, peripheral edema, orthostatic hypotension, headache, somnolence, nervousness, dream abnormality, agitation, dry nose, diarrhea and fatigue.

Infrequently (0.1-1%) occurring adverse reactions are: congestive heart failure, psychosis, urinary retention, dyspnea, skin rash, vomiting, weakness, slurred speech, euphoria, thinking abnormality, amnesia, hyperkinesia, hypertension, decreased libido, and visual disturbance, including punctate subepithelial or other corneal opacity, corneal edema, decreased visual acuity, sensitivity to light, and optic nerve palsy.

Rare (less than 0.1%) occurring adverse reactions are: instances of convulsion, leukopenia, neutropenia, eczematoid dermatitis, oculogyric episodes, suicidal attempt, suicide, and suicidal ideation (see WARNINGS).

Other adverse reactions reported during postmarketing experience with SYMMETREL (amantadine hydrochloride) usage include:

Nervous System/Psychiatric

coma, stupor, delirium, hypokinesia, hypertonia, delusions, aggressive behavior, paranoid reaction, manic reaction, involuntary muscle contractions, gait abnormalities, paresthesia, EEG changes, and tremor. Abrupt discontinuation may also precipitate delirium, agitation, delusions, hallucinations, paranoid reaction, stupor, anxiety, depression and slurred speech;

Cardiovascular

cardiac arrest, arrhythmias including malignant arrhythmias, hypotension, and tachycardia;

Respiratory

acute respiratory failure, pulmonary edema, and tachypnea;

Gastrointestinal

dysphagia;

Hematologic

leukocytosis; agranulocytosis

Special Senses

keratitis and mydriasis;

Skin and Appendages

pruritus and diaphoresis;

Miscellaneous

neuroleptic malignant syndrome (see WARNINGS), allergic reactions including anaphylactic reactions, edema, fever, pathological gambling, increased libido including hypersexuality, and impulse control symptoms.

Laboratory Test

elevated: CPK, BUN, serum creatinine, alkaline phosphatase, LDH, bilirubin, GGT, SGOT, and SGPT.

Read the entire FDA prescribing information for Symmetrel (Amantadine Hydrochloride)

Related Resources for Symmetrel

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© Symmetrel Patient Information is supplied by Cerner Multum, Inc. and Symmetrel Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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