Synvisc

Drug Description
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Synvisc®
(hylan G-F 20)

DRUG DESCRIPTION

Synvisc® (hylan G-F 20) is an elastoviscous fluid containing hylan polymers produced from chicken combs. Hylans are derivatives of hyaluronan (sodium hyaluronate), a natural complex sugar of the glycosaminoglycan family. Hyaluronan is a long-chain polymer containing repeating disaccharide units of Na-glucuronate-N-acetylglucosamine.

Detailed Device Description

Synvisc contains hylan A (average molecular weight 6,000,000) and hylan B hydrated gel in a buffered physiological sodium chloride solution, pH 7.2. Synvisc has an elasticity (storage modulus G') at 2.5 Hz of 111 ± 13 Pascals (Pa) and a viscosity (loss modulus G“) of 25 ± 2 Pa (elasticity and viscosity of knee synovial fluid of 18 to 27-year-old humans measured with a comparable method at 2.5 Hz: G' = 117 ± 13 Pa; G“ = 45 ± 8 Pa.)

Each syringe of Synvisc contains:

Hylan polymers (hylan A + hylan B) 16 mg
Sodium chloride 17 mg
Disodium hydrogen phosphate 0.32 mg
Sodium dihydrogen phosphate monohydrate 0.08 mg
Water for injection q.s. to 2.0 mL

Last updated on RxList: 3/30/2009

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