DOSAGE AND ADMINISTRATION
Directions For Use
SYNVISC (hylan g-f 20) is administered by intra-articular injection once a week (one week apart) for a total of three injections.
Precaution: Do not use SYNVISC (hylan g-f 20) if the package has been opened or damaged. Store in original packaging (protected from light) at room temperature below 86°F (30°C).DO NOT FREEZE.
Precaution: The syringe containing SYNVISC (hylan g-f 20) is intended for single use. The contents of the syringe must be used immediately after the syringe has been removed from its packaging.
Precaution: Do not concomitantly use disinfectants containing quaternary ammonium salts for skin preparation because hyaluronan can precipitate in their presence.
SYNVISC (hylan g-f 20) is administered by intra-articular injection once a week (one week apart) for a total of three injections. Strict aseptic administration technique must be followed.
- Using an 18- to 22-gauge needle, remove synovial fluid or effusion before each SYNVISC (hylan g-f 20) injection.
- Do not use the same syringe for removing synovial fluid and for injecting SYNVISC (hylan g-f 20) however the same 18- to 22-gauge needle should be used.
- Twist the tip cap before pulling it off, as this will minimize product leakage.
- To ensure a tight seal and prevent leakage during administration, secure the needle tightly while firmly holding the luer hub.
Precaution: Do not over tighten or apply excessive leverage when attaching the needle or removing the needle guard, as this may break the syringe tip.
Inject the full 2 mL in one knee only.
SYNVISC (hylan g-f 20) is supplied in a 2.25 mL glass syringe containing one 2 mL (16 mg) dose of hylan G-F 20. The contents of the syringe are sterile and nonpyrogenic.
MANUFACTURED AND DISTRIBUTED BY: Genzyme Biosurgery a division of Genzyme Corporation, 1125 Pleasant View Terrace, Ridgefield, New Jersey 07657. Telephone: 1-888-3-SYNVISC (hylan g-f 20) (1-888-379-6847).
Last reviewed on RxList: 7/22/2010
This monograph has been modified to include the generic and brand name in many instances.
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