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How Supplied


SYNVISC (hylan g-f 20) is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative nonpharmacologic therapy and simple analgesics, e.g., acetaminophen.


Directions For Use

SYNVISC (hylan g-f 20) is administered by intra-articular injection once a week (one week apart) for a total of three injections.

Precaution: Do not use SYNVISC (hylan g-f 20) if the package has been opened or damaged. Store in original packaging (protected from light) at room temperature below 86°F (30°C).DO NOT FREEZE.

Precaution: The syringe containing SYNVISC (hylan g-f 20) is intended for single use. The contents of the syringe must be used immediately after the syringe has been removed from its packaging.

Precaution: Do not concomitantly use disinfectants containing quaternary ammonium salts for skin preparation because hyaluronan can precipitate in their presence.

SYNVISC (hylan g-f 20) is administered by intra-articular injection once a week (one week apart) for a total of three injections. Strict aseptic administration technique must be followed.

  • Using an 18- to 22-gauge needle, remove synovial fluid or effusion before each SYNVISC (hylan g-f 20) injection.
  • Do not use the same syringe for removing synovial fluid and for injecting SYNVISC (hylan g-f 20) however the same 18- to 22-gauge needle should be used.
  • Twist the tip cap before pulling it off, as this will minimize product leakage.
  • To ensure a tight seal and prevent leakage during administration, secure the needle tightly while firmly holding the luer hub.

Precaution: Do not over tighten or apply excessive leverage when attaching the needle or removing the needle guard, as this may break the syringe tip.

Inject the full 2 mL in one knee only.


SYNVISC (hylan g-f 20) is supplied in a 2.25 mL glass syringe containing one 2 mL (16 mg) dose of hylan G-F 20. The contents of the syringe are sterile and nonpyrogenic.

MANUFACTURED AND DISTRIBUTED BY: Genzyme Biosurgery a division of Genzyme Corporation, 1125 Pleasant View Terrace, Ridgefield, New Jersey 07657. Telephone: 1-888-3-SYNVISC (hylan g-f 20) (1-888-379-6847).

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 7/22/2010

How Supplied

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