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(hylan G-F 20) Injection
Synvisc-One® (hylan G-F 20) is an elastoviscous high molecular weight fluid containing hylan A and hylan B polymers produced from chicken combs. Hylans are derivatives of hyaluronan (sodium hyaluronate). Hylan G-F 20 is unique in that the hyaluronan is chemically crosslinked. Hyaluronan is a long-chain polymer containing repeating disaccharide units of Na-glucuronate-N-acetylglucosamine.
What are the possible side effects of hylan G-F 20 (Synvisc, Synvisc-One)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have severe pain or swelling around the knee after the injection.
Less serious side effects may include:
- warmth, pain, stiffness, swelling, or puffiness where the medicine was injected;
- muscle pain, trouble walking;
- fever, chills, nausea;
- numbness or tingly feeling;
- headache, dizziness;
- tired feeling; or
What are the precautions when taking hylan g-f 20 single intra-articular injection (Synvisc-One)?
Before using hyaluronate, tell your doctor or pharmacist if you are allergic to it; or to bird proteins, feathers, or egg products; or if you have any other allergies. This product may contain inactive ingredients (such as latex found in the rubber syringe cap of some brands), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: knee joint infections, skin infections/problems in the area around the injection site, circulation problems in the legs.
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
It is unknown whether this drug passes into breast milk....
Last reviewed on RxList: 5/6/2016
This monograph has been modified to include the generic and brand name in many instances.
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