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(trientine hydrochloride) Capsule


Trientine hydrochloride is N,N'-bis (2-aminoethyl)-1,2-ethanediamine dihydrochloride. It is a white to pale yellow crystalline hygroscopic powder. It is freely soluble in water, soluble in methanol, slightly soluble in ethanol, and insoluble in chloroform and ether.

The empirical formula is C6H18N4•2HCl with a molecular weight of 219.2. The structural formula is:


Trientine hydrochloride is a chelating compound for removal of excess copper from the body. SYPRINE1 (Trientine Hydrochloride) is available as 250 mg capsules for oral administration. Capsules SYPRINE (trientine) contain gelatin, iron oxides, stearic acid, and titanium dioxide as inactive ingredients.

What are the possible side effects of trientine (Syprine)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • cough, trouble breathing;
  • pale skin, easy bruising or bleeding, weakness;
  • tired feeling, muscle or joint pain, swollen glands;
  • seizure (convulsions);
  • muscle weakness, dropping eyelids, double vision; or
  • problems with speech, balance, walking, lifting, chewing, or swallowing;

Less serious...

Read All Potential Side Effects and See Pictures of Syprine »

Last reviewed on RxList: 5/19/2009
This monograph has been modified to include the generic and brand name in many instances.


Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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