August 23, 2016
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Syprine Patient Information including How Should I Take

What should I discuss with my health care provider before taking trientine (Syprine)?

You should not use this medication if you are allergic to trientine.

Before using trientine, tell your doctor if you are allergic to any drugs, or if you have:

  • rheumatoid arthritis;
  • a kidney or bladder condition called cystinuria; or
  • a liver condition called biliary cirrhosis.

If you have any of these conditions, you may need dose adjustments or special tests during treatment.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether trientine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take trientine (Syprine)?

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Take the trientine capsule with water. Do not take trientine with milk.

Take trientine on an empty stomach, at least 1 hour before or 2 hours after eating a meal or snack or taking any other medicines.

Trientine is usually taken 2 to 4 times each day. Follow your doctor's instructions.

Do not chew or open a trientine capsule. Swallow the pill whole.

Do not use a capsule that has been accidentally broken. The medicine from a broken capsule can be dangerous if it gets on your skin. If skin contact occurs, rinse the area thoroughly with plain water. Watch for signs of skin irritation and call your doctor if you develop a rash.

You may need to take your temperature every night for at least the first month of treatment with trientine. Call your doctor if you have a fever.

To be sure this medication is helping your condition, your blood will need to be tested often. Your iron levels will also be checked to make sure they don't get too low. Do not miss any scheduled appointments.

Store this medication in the refrigerator and do not allow it to freeze.

Side Effects Centers

Additional Syprine Information

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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