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Syprine Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Syprine (trientine) is used to treat Wilson's disease in people who cannot take penicillamine (Cuprimine, Depen). It is a chelating agent that works by removing heavy metals from the blood. Common side effects include skin rash, muscle spasm or contractions, heartburn, stomach pain, loss of appetite, or skin flaking, cracking, or thickening.
The recommended initial dose of Syprine is 500-750 mg/day for pediatric patients and 750-1250 mg/day for adults given in divided doses two, three or four times daily. This may be increased to a maximum of 2000 mg/day for adults or 1500 mg/day for pediatric patients age 12 or under. Other drugs may interact with Syprine. Tell your doctor all medications and supplements you use. During pregnancy, Syprine should be taken only if prescribed. It may be harmful to a fetus. It is unknown if this drug passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding.
Our Syprine (trientine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Syprine in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
- cough, trouble breathing;
- pale skin, easy bruising or bleeding, weakness;
- tired feeling, muscle or joint pain, swollen glands;
- seizure (convulsions);
- muscle weakness, dropping eyelids, double vision; or
- problems with speech, balance, walking, lifting, chewing, or swallowing;
Less serious side effects include:
- skin rash;
- muscle spasm or contractions;
- stomach pain;
- loss of appetite; or
- skin flaking, cracking, or thickening;
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Syprine (Trientine) »
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Syprine FDA Prescribing Information: Side Effects
Clinical experience with SYPRINE (trientine) has been limited. The following adverse reactions have been reported in a clinical study in patients with Wilson's disease who were on therapy with trientine hydrochloride: iron deficiency, systemic lupus erythematosus (see CLINICAL PHARMACOLOGY). In addition, the following adverse reactions have been reported in marketed use: dystonia, muscular spasm, myasthenia gravis.
SYPRINE (trientine) is not indicated for treatment of biliary cirrhosis, but in one study of 4 patients treated with trientine hydrochloride for primary biliary cirrhosis, the following adverse reactions were reported: heartburn; epigastric pain and tenderness; thickening, fissuring and flaking of the skin; hypochromic microcytic anemia; acute gastritis; aphthoid ulcers; abdominal pain; melena; anorexia; malaise; cramps; muscle pain; weakness; rhabdomyolysis. A causal relationship of these reactions to drug therapy could not be rejected or established.
Read the entire FDA prescribing information for Syprine (Trientine) »
Additional Syprine Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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