"The U.S. Food and Drug Administration today expanded the approved use of Imbruvica (ibrutinib) to treat patients with chronic lymphocytic leukemia (CLL) who carry a deletion in chromosome 17 (17p deletion), which is associated with poor responses"...
(thioguanine 40-mg) Scored Tablets
TABLOID brand Thioguanine is a potent drug. It should not be used unless a diagnosis of acute nonlymphocytic leukemia has been adequately established and the responsible physician is knowledgeable in assessing response to chemotherapy.
TABLOID brand Thioguanine was synthesized and developed by Hitchings, Elion, and associates at the Wellcome Research Laboratories. It is one of a large series of purine analogues which interfere with nucleic acid biosynthesis, and has been found active against selected human neoplastic diseases.
Thioguanine, known chemically as 2-amino-1,7-dihydro-6H-purine-6-thione, is an analogue of the nucleic acid constituent guanine, and is closely related structurally and functionally to PURINETHOL® (mercaptopurine). Its structural formula is:
TABLOID brand Thioguanine is available in tablets for oral administration. Each scored tablet contains 40 mg thioguanine and the inactive ingredients gum acacia, lactose, magnesium stearate, potato starch, and stearic acid.
What are the possible side effects of thioguanine (Tabloid)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using thioguanine and call your doctor at once if you have any of these serious side effects:
- pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
- fever, chills, body aches, flu symptoms, sores or white patches in your mouth and throat;
- easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your...
What are the precautions when taking thioguanine (Tabloid)?
Before taking thioguanine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before taking this medicine, consult your doctor or pharmacist if a certain drug (mercaptopurine) did not work for you in the past. This may affect how well thioguanine works for you.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: other blood disorders (e.g., anemia, low blood cell counts), gout, kidney stones, liver disease.
Do not have immunizations/vaccinations without the consent of your doctor, and avoid contact with people who have recently received...
Last reviewed on RxList: 7/25/2008
This monograph has been modified to include the generic and brand name in many instances.
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