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Tabloid

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Tabloid

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TABLOID®
(thioguanine 40-mg) Scored Tablets

CAUTION

TABLOID brand Thioguanine is a potent drug. It should not be used unless a diagnosis of acute nonlymphocytic leukemia has been adequately established and the responsible physician is knowledgeable in assessing response to chemotherapy.

DRUG DESCRIPTION

TABLOID brand Thioguanine was synthesized and developed by Hitchings, Elion, and associates at the Wellcome Research Laboratories. It is one of a large series of purine analogues which interfere with nucleic acid biosynthesis, and has been found active against selected human neoplastic diseases.

Thioguanine, known chemically as 2-amino-1,7-dihydro-6H-purine-6-thione, is an analogue of the nucleic acid constituent guanine, and is closely related structurally and functionally to PURINETHOL® (mercaptopurine). Its structural formula is:

TABLOID® brand Thioguanine Structural Formula Illustration

TABLOID brand Thioguanine is available in tablets for oral administration. Each scored tablet contains 40 mg thioguanine and the inactive ingredients gum acacia, lactose, magnesium stearate, potato starch, and stearic acid.

What are the possible side effects of thioguanine ()?

If you experience any of the following serious side effects, seek emergency medical attention or contact your doctor immediately:

  • an allergic reaction (shortness of breath; closing of the throat; difficulty breathing; swelling of the lips, face, or tongue; or hives);
  • abdominal pain;
  • jaundice (yellowing of the skin or eyes);
  • extreme fatigue;
  • signs of infection such as fever; chills, or sore throat;
  • unusual bleeding or bruising;
  • black, bloody or tarry stools; or
  • ...

Read All Potential Side Effects and See Pictures of Tabloid »

What are the precautions when taking thioguanine (Tabloid)?

Before taking thioguanine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before taking this medicine, consult your doctor or pharmacist if a certain drug (mercaptopurine) did not work for you in the past. This may affect how well thioguanine works for you.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: other blood disorders (e.g., anemia, low blood cell counts), gout, kidney stones, liver disease.

Do not have immunizations/vaccinations without the consent of your doctor, and avoid contact with people who have recently received...

Read All Potential Precautions of Tabloid »

Last reviewed on RxList: 7/25/2008
This monograph has been modified to include the generic and brand name in many instances.

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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