"The US Food and Drug Administration (FDA) has approved a foam containing calcipotriene and betamethasone dipropionate (Enstilar, Leo Pharma Inc) for topical treatment of plaque psoriasis in adults 18 years of age and older, according to a "...
(calcipotriene and betamethasone dipropionate) Topical Suspension
Chemically, calcipotriene hydrate is 9,10-secochola-5,7,10(19),22-tetraene-1,3,24-triol,24-cyclo-propyl-,monohydrate, (1α,3ß,5Z,7E,22E,24S) with the empirical formula C27H40O3,H20, a molecular weight of 430.6, and the following structural formula:
Calcipotriene hydrate is a white to almost white, crystalline compound. Betamethasone dipropionate is a synthetic corticosteroid. Betamethasone dipropionate has the chemical name Pregna-1,4-diene-3,20-dione-9-fluoro-11-hydroxy-16-methyl-17,21-bis(1-oxypropoxy)-(11β,16β), with the empirical formula C28H37FO7, a molecular weight of 504.6, and the following structural formula:
Betamethasone dipropionate is a white to almost white, crystalline powder.
Each gram of Taclonex® Topical Suspension contains 52.18 mcg of calcipotriene hydrate (equivalent to 50 mcg of calcipotriene) and 0.643 mg of betamethasone dipropionate (equivalent to 0.5 mg of betamethasone) in a base of hydrogenated castor oil, polyoxypropylene stearyl ether, all-rac-alpha-tocopherol, butylhydroxytoluene, and mineral oil. Taclonex® Topical Suspension is an odorless clear to slightly off white suspension.
What are the possible side effects of betamethasone and calcipotriene (Taclonex, Taclonex Scalp)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using betamethasone and calcipotriene and call your doctor at once if you have any of these serious side effects:
- severe skin irritation on treated areas;
- worsened symptoms or no improvement in psoriasis;
- pus, swelling, redness, increased itching, or other signs of skin infection;
- confusion, thirst, extreme tiredness, lost appetite, weight...
What are the precautions when taking calcipotriene and betamethasone dipropionate topical suspension (Taclonex Scalp)?
Before using this medication, tell your doctor or pharmacist if you are allergic to betamethasone or calcipotriene; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor your medical history, especially of: a certain mineral imbalance (high calcium levels in the blood or urine), thin skin in the area to be treated, liver disease.
If you have a skin infection (such as chickenpox, herpes simplex) or a skin problem other than psoriasis, it should be treated before you start this medication. Betamethasone and other corticosteroid drugs can slow down your body's response to antibiotic drugs and make it more...
Last reviewed on RxList: 7/6/2016
This monograph has been modified to include the generic and brand name in many instances.
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