August 29, 2016
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Talwin Compound

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Talwin Compound

Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Talwin Compound Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 4/28/2016

Talwin Compound (pentazocine and aspirin) is a combination opiate (narcotic) analgesic and nonsteroidal anti-inflammatory drug (NSAID) used to relieve moderate pain. The brand name Talwin Compound is discontinued, but generic versions may be available. Common side effects of Talwin Compound (pentazocine and aspirin) include:

Less common side effects of Talwin Compound (pentazocine and aspirin) include:

  • constipation
  • abdominal discomfort
  • diarrhea
  • weakness
  • insomnia
  • blurred vision
  • flushing
  • rash
  • decreased blood pressure, and
  • urinary retention

The usual adult dose of Talwin Compound is 2 caplets three or four times a day. Talwin Compound may interact with other drugs. Tell your doctor all medications and supplements you use. During pregnancy, Talwin Compound should be used only if prescribed. Consult your doctor before breastfeeding. Withdrawal symptoms may occur if you suddenly stop taking this medication.

Our Talwin Compound (pentazocine and aspirin) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Talwin Compound FDA Prescribing Information: Side Effects
(Adverse Reactions)


Reactions reported after oral administration of pentazocine or TALWIN Compound (pentazocine and aspirin) include Gastrointestinal: nausea, vomiting; infrequently constipation; and rarely abdominal distress, anorexia, diarrhea. CNS Effects: dizziness, lightheadedness, hallucinations, sedation, euphoria, headache, confusion, disorientation; infrequently weakness, disturbed dreams, insomnia, syncope, visual blurring and focusing difficulty, depression; and rarely tremor, irritability, excitement, tinnitus. Autonomic: sweating; infrequently flushing; and rarely chills. Allergic: infrequently rash; and rarely urticaria, edema of the  face, and angioneurotic edema. Cardiovascular:  infrequently decrease in blood pressure, tachycardia. Hematologic: rarely depression of white blood cells (especially granulocytes), which is usually reversible, moderate transient eosinophilia. Other: rarely respiratory depression, urinary retention, paresthesia, angioneurotic edema, serious skin reactions, including erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis.


Read the entire FDA prescribing information for Talwin Compound (Pentazocine and Aspirin)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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