Talwin Nx (Pentazocine and Naloxone) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 21, 2012

Talwin Nx

Pain Management: Musculoskeletal Pain »

What Causes Musculoskeletal Pain?

The causes of musculoskeletal pain are varied. Muscle tissue can be damaged with the wear and tear of daily activities. Trauma to an area (jerking movements, auto accidents, falls, fractures, sprains, dislocations, and direct blows to the muscle) also can cause musculoskeletal pain. Other causes of pain include postural strain, repetitive movements, overuse, and prolonged immobilization. Changes in posture or poor body mechanics may bring about spinal alignment problems and muscle shortening, therefore causing other muscles to be misused and become painful.

What Are the Symptoms of Musculoskeletal Pain?

People with musculoskeletal pain sometimes complain that their entire bodies ache. Their muscles may feel like they have been pulled or overworked. Sometimes the muscles twitch or burn. Symptoms vary from person to person, but the common symptoms are:

Pain
Fatigue
Sl...

Read the Pain Management: Musculoskeletal Pain article »

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Talwin Nx

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TALWIN® NX
(pentazocine hydrochloride and naloxone hydrochloride, USP)

Analgesic for Oral Use Only

WARNING: TALWIN® NX (pentazocine and naloxone) is intended for oral use only. Severe, potentially lethal, reactions may result from misuse of TALWIN® NX (pentazocine and naloxone) by injection either alone or in combination with other substances. (See Drug Abuse and Dependence section.)

DRUG DESCRIPTION

TALWIN NX (pentazocine and naloxone hydrochlorides, USP) contains pentazocine hydrochloride, USP, equivalent to 50 mg base and is a member of the benzazocine series (also known as the benzomorphan series), and naloxone hydrochloride, USP, equivalent to 0.5 mg base.

TALWIN NX (pentazocine and naloxone) is an analgesic for oral administration.

Chemically, pentazocine hydrochloride is (2R*,6R*,11R*)-l,2,3,4,5,6-Hexahydro-6,ll-dimethyl-3-(3-methyl-2-butenyl)-2,6-methano-3-benzazocin-8-ol hydrochloride, a white, crystalline substance soluble in acidic aqueous solutions, and has the following structural formula:

pentazocine hydrochloride Structural Formula Illustration

C₁₉H₂₇NO·HCl............M.W. 321.88

Chemically, naloxone hydrochloride is Morphinan-6-one,4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, hydrochloride, (5α)-. It is a slightly off-white powder, and is soluble in water and dilute acids, and has the following structural formula:

naloxone hydrochloride Structural Formula Illustration

C₁₉H₂₁NO₄·HCl..............M.W.=363.84

Inactive Ingredients: Colloidal Silicon Dioxide, Dibasic Calcium Phosphate, D&C Yellow #10, FD&C Yellow #6, Magnesium Stearate, Microcrystalline Cellulose, Sodium Lauryl Sulfate, Starch.

What are the possible side effects of naloxone and pentazocine (Talwin NX)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using naloxone and pentazocine and call your doctor at once if you have any of these serious side effects:

confusion, hallucinations;
fast heart rate;
weak or shallow breathing;
chest pain;
seizure (convulsions);
cold, clammy skin;
tremors;
confusion, unusual...

Read All Potential Side Effects and See Pictures of Talwin Nx »

What are the precautions when taking pentazocine and naloxone (Talwin Nx)?

Before taking this product, tell your doctor or pharmacist if you are allergic to pentazocine or naloxone; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: certain bowel diseases (paralytic ileus, infectious diarrhea).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, lung disease (such as asthma, chronic obstructive pulmonary disease-COPD), a certain spinal problem (kyphoscoliosis), breathing problems (such as...

Read All Potential Precautions of Talwin Nx »

Last reviewed on RxList: 4/13/2011
This monograph has been modified to include the generic and brand name in many instances.