"Nov. 2, 2012 -- Safety steps taken in the wake of the fungal meningitis outbreak have worsened drug shortages, raising questions about whether the U.S. must choose between the safety and the availability of crucial medicines.
Rarely, respiratory depression.
Acute CNS Manifestations
Hallucinations (usually visual), disorientation, and confusion .
Other CNS Effects
Grand mal convulsions, increase in intracranial pressure, dizziness, lightheadedness, hallucinations, sedation, euphoria, headache, confusion, disorientation; infrequently weakness, disturbed dreams, insomnia, syncope, and depression; and rarely tremor, irritability, excitement, tinnitus.
Visual blurring and focusing difficulty, miosis.
Dependence and Withdrawal Symptoms
Urinary retention, paresthesia, serious skin reactions, including erythema multiforme, Stevens-Johnson syndrome toxic epidermal necrolysis, and alterations in rate or strength of uterine contractions during labor.
Read the Talwin Nx (pentazocine and naloxone) Side Effects Center for a complete guide to possible side effects »
Other central nervous system (CNS) depressants including sedatives, hypnotics, general anesthetics, antiemetics, phenothiazines, or other tranquilizers or alcohol increases the risk of respiratory depression, hypotension, profound sedation, or coma. Use morphine sulfate with caution and in reduced dosages in patients taking these agents.
Opioid Agonist Analgesics
TALWIN NX (pentazocine and naloxone) can antagonize the effects of a pure opioid agonist analgesic and/or may precipitate withdrawal symptoms.
Monoamine Oxidase Inhibitors (MAOIs)
Concomitant use of monoamine oxidase inhibitors (MAOIs) with TALWIN NX (pentazocine and naloxone) may cause CNS excitation and hypertension through their respective effects on catecholamines. Caution should therefore be observed in administering TALWIN NX (pentazocine and naloxone) to patients who are currently receiving MAOIs or who have received them within the preceding 14 days
Anticholinergics or other medications with anticholinergic activity when used concurrently with opioid analgesics may result in increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus.
Smoking tobacco could enhance the metabolic clearance rate of pentazocine reducing the clinical effectiveness of a standard dose of pentazocine.
Last reviewed on RxList: 4/13/2011
This monograph has been modified to include the generic and brand name in many instances.
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