October 4, 2015
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Talwin Nx

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Talwin Nx

Side Effects



Hypertension, hypotension, circulatory depression, tachycardia, syncope.


Rarely, respiratory depression.

Acute CNS Manifestations

Hallucinations (usually visual), disorientation, and confusion .

Other CNS Effects

Grand mal convulsions, increase in intracranial pressure, dizziness, lightheadedness, hallucinations, sedation, euphoria, headache, confusion, disorientation; infrequently weakness, disturbed dreams, insomnia, syncope, and depression; and rarely tremor, irritability, excitement, tinnitus.


Sweating; infrequently flushing; and rarely chills.


Nausea, vomiting, constipation, diarrhea, anorexia, dry mouth, biliary tract spasm, and rarely abdominal distress.


Edema of the face; anaphylactic shock; dermatitis, including pruritus; flushed skin, including plethora; infrequently rash, and rarely urticaria.


Visual blurring and focusing difficulty, miosis.


Depression of white blood cells (especially granulocytes), with rare cases of agranulocytosis, which is usually reversible, moderate transient eosinophilia.

Dependence and Withdrawal Symptoms

(See WARNINGS, PRECAUTIONS, and Drug Abuse and DependenceSections).


Urinary retention, paresthesia, serious skin reactions, including erythema multiforme, Stevens-Johnson syndrome toxic epidermal necrolysis, and alterations in rate or strength of uterine contractions during labor.

Read the Talwin Nx (pentazocine and naloxone) Side Effects Center for a complete guide to possible side effects


CNS Depressants

Other central nervous system (CNS) depressants including sedatives, hypnotics, general anesthetics, antiemetics, phenothiazines, or other tranquilizers or alcohol increases the risk of respiratory depression, hypotension, profound sedation, or coma. Use morphine sulfate with caution and in reduced dosages in patients taking these agents.

Opioid Agonist Analgesics

TALWIN NX (pentazocine and naloxone) can antagonize the effects of a pure opioid agonist analgesic and/or may precipitate withdrawal symptoms.

Monoamine Oxidase Inhibitors (MAOIs)

Concomitant use of monoamine oxidase inhibitors (MAOIs) with TALWIN NX (pentazocine and naloxone) may cause CNS excitation and hypertension through their respective effects on catecholamines. Caution should therefore be observed in administering TALWIN NX (pentazocine and naloxone) to patients who are currently receiving MAOIs or who have received them within the preceding 14 days


Anticholinergics or other medications with anticholinergic activity when used concurrently with opioid analgesics may result in increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus.


Smoking tobacco could enhance the metabolic clearance rate of pentazocine reducing the clinical effectiveness of a standard dose of pentazocine.

Read the Talwin Nx Drug Interactions Center for a complete guide to possible interactions

Last reviewed on RxList: 4/13/2011
This monograph has been modified to include the generic and brand name in many instances.

Side Effects

Talwin Nx - User Reviews

Talwin Nx User Reviews

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Here is a collection of user reviews for the medication Talwin Nx sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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