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Talwin Nx

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Talwin Nx

Talwin Nx Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Talwin Nx (pentazocine hydrochloride and naloxone hydrochloride, USP) is used to treat moderate to severe pain. It contains 2 medications, pentazocine, a narcotic pain reliever (opiate-type), and naloxone, an opioid antagonist, which helps to prevent misuse of this drug by blocking the effect of pentazocine. Common side effects include nausea, vomiting, constipation, lightheadedness, dizziness, drowsiness, increased sweating, or dry mouth.

The dosage is based on the individual patient's medical condition and response to treatment. Talwin Nx may adversely interact with naltrexone, sibutramine, fluoxetine, MAO inhibitors, alcohol, anti-seizure drugs, medicine for sleep or anxiety, muscle relaxants, psychiatric medicines or any medication that may cause drowsiness or affect breathing. During pregnancy, this medication should be used only when prescribed. Using it near the expected delivery date is not recommended because of possible harm to the fetus. Discuss the risks and benefits with your doctor. Infants born to mothers who have used this medication may have withdrawal symptoms such as irritability, abnormal/persistent crying, vomiting, or diarrhea. Tell your doctor immediately if you notice any of these symptoms in your newborn. It is unknown if this product passes into breast milk. Discuss the risks and benefits with your doctor before breast-feeding. Do not stop using Talwin Nx suddenly after long-term use, or you could have withdrawal symptoms.

Our Talwin Nx Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Talwin Nx in Detail - Patient Information: Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using naloxone and pentazocine and call your doctor at once if you have any of these serious side effects:

  • confusion, hallucinations;
  • fast heart rate;
  • weak or shallow breathing;
  • chest pain;
  • seizure (convulsions);
  • cold, clammy skin;
  • tremors;
  • confusion, unusual thoughts or behavior;
  • severe anxiety or restlessness; or
  • feeling like you might pass out.

Less serious side effects may include:

  • dizziness, drowsiness;
  • headache, weakness;
  • sleep problems (insomnia), strange dreams;
  • diarrhea, constipation;
  • nausea, vomiting, loss of appetite;
  • warmth, redness, or tingly feeling under your skin;
  • sweating;
  • blurred vision; or
  • ringing in your ears.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Talwin Nx (Pentazocine and Naloxone) »

What is Patient Information Overview?

A concise overview of the drug for the patient or caregiver from First DataBank.

Talwin Nx Overview - Patient Information: Side Effects

SIDE EFFECTS: Nausea, vomiting, constipation, lightheadedness, dizziness, drowsiness, increased sweating, or dry mouth may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

To prevent constipation, maintain a diet adequate in fiber, drink plenty of water, and exercise. Consult your pharmacist for help in selecting a laxative (such as a stimulant type with stool softener).

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as agitation, hallucinations, confusion), difficulty urinating, vision changes, fast heartbeat, severe stomach/abdominal pain, change in the amount of urine, signs of infection (such as fever, persistent sore throat).

Get medical help right away if you have any very serious side effects, including: slow/shallow breathing, seizures, fainting.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Read the entire patient information overview for Talwin Nx (Pentazocine and Naloxone)»

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Talwin Nx FDA Prescribing Information: Side Effects
(Adverse Reactions)

SIDE EFFECTS

Cardiovascular

Hypertension, hypotension, circulatory depression, tachycardia, syncope.

Respiratory

Rarely, respiratory depression.

Acute CNS Manifestations

Hallucinations (usually visual), disorientation, and confusion .

Other CNS Effects

Grand mal convulsions, increase in intracranial pressure, dizziness, lightheadedness, hallucinations, sedation, euphoria, headache, confusion, disorientation; infrequently weakness, disturbed dreams, insomnia, syncope, and depression; and rarely tremor, irritability, excitement, tinnitus.

Autonomic

Sweating; infrequently flushing; and rarely chills.

Gastrointestinal

Nausea, vomiting, constipation, diarrhea, anorexia, dry mouth, biliary tract spasm, and rarely abdominal distress.

Allergic

Edema of the face; anaphylactic shock; dermatitis, including pruritus; flushed skin, including plethora; infrequently rash, and rarely urticaria.

Ophthalmic

Visual blurring and focusing difficulty, miosis.

Hematologic

Depression of white blood cells (especially granulocytes), with rare cases of agranulocytosis, which is usually reversible, moderate transient eosinophilia.

Dependence and Withdrawal Symptoms

(See WARNINGS, PRECAUTIONS, and Drug Abuse and DependenceSections).

Other

Urinary retention, paresthesia, serious skin reactions, including erythema multiforme, Stevens-Johnson syndrome toxic epidermal necrolysis, and alterations in rate or strength of uterine contractions during labor.

Read the entire FDA prescribing information for Talwin Nx (Pentazocine and Naloxone) »

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Talwin Nx - User Reviews

Talwin Nx User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Talwin Nx sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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