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Talwin Nx Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Talwin Nx (pentazocine hydrochloride and naloxone hydrochloride) is a combination of a narcotic pain reliever (opiate-type) and an opioid antagonist used to treat moderate to severe pain. Common side effects of Talwin Nx include nausea, vomiting, loss of appetite, constipation, diarrhea, lightheadedness, dizziness, drowsiness, increased sweating, dry mouth, headache, weakness, restlessness, irritability, tremor, chills, flushing (warmth, redness, or tingly feeling), sleep problems (insomnia), strange dreams, blurred vision, or ringing in your ears.
The dosage is based on the individual patient's medical condition and response to treatment. Talwin Nx may adversely interact with naltrexone, sibutramine, fluoxetine, MAO inhibitors, alcohol, anti-seizure drugs, medicine for sleep or anxiety, muscle relaxants, psychiatric medicines or any medication that may cause drowsiness or affect breathing. During pregnancy, this medication should be used only when prescribed. Using it near the expected delivery date is not recommended because of possible harm to the fetus. Discuss the risks and benefits with your doctor. Infants born to mothers who have used this medication may have withdrawal symptoms such as irritability, abnormal/persistent crying, vomiting, or diarrhea. Tell your doctor immediately if you notice any of these symptoms in your newborn. It is unknown if this product passes into breast milk. Discuss the risks and benefits with your doctor before breast-feeding. Do not stop using Talwin Nx suddenly after long-term use, or you could have withdrawal symptoms.
Our Talwin Nx Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Talwin Nx in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have a serious side effect such as:
- weak or shallow breathing, slow heartbeats;
- confusion, hallucinations, unusual thoughts or behavior;
- severe weakness or dizziness;
- seizure (convulsions);
- feeling like you might pass out; or
- severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Less serious side effects may include:
- dizziness, drowsiness;
- headache, weakness;
- feeling restless or irritable;
- diarrhea, constipation;
- dry mouth, nausea, vomiting, loss of appetite;
- tremor, chills, sweating;
- flushing (warmth, redness, or tingly feeling);
- sleep problems (insomnia), strange dreams;
- blurred vision; or
- ringing in your ears.
Read the entire detailed patient monograph for Talwin Nx (Pentazocine and Naloxone)
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Talwin Nx Overview - Patient Information: Side Effects
To prevent constipation, maintain a diet adequate in fiber, drink plenty of water, and exercise. Consult your pharmacist for help in selecting a laxative (such as a stimulant type with stool softener).
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as agitation, hallucinations, confusion), difficulty urinating, vision changes, fast heartbeat, severe stomach/abdominal pain, change in the amount of urine, signs of infection (such as fever, persistent sore throat).
Get medical help right away if you have any very serious side effects, including: slow/shallow breathing, seizures, fainting.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Talwin Nx (Pentazocine and Naloxone)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Talwin Nx FDA Prescribing Information: Side Effects
Rarely, respiratory depression.
Acute CNS Manifestations
Hallucinations (usually visual), disorientation, and confusion .
Other CNS Effects
Grand mal convulsions, increase in intracranial pressure, dizziness, lightheadedness, hallucinations, sedation, euphoria, headache, confusion, disorientation; infrequently weakness, disturbed dreams, insomnia, syncope, and depression; and rarely tremor, irritability, excitement, tinnitus.
Visual blurring and focusing difficulty, miosis.
Dependence and Withdrawal Symptoms
Urinary retention, paresthesia, serious skin reactions, including erythema multiforme, Stevens-Johnson syndrome toxic epidermal necrolysis, and alterations in rate or strength of uterine contractions during labor.
Read the entire FDA prescribing information for Talwin Nx (Pentazocine and Naloxone)
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