July 26, 2016
Recommended Topic Related To:


"The US Food and Drug Administration (FDA) has approved an expanded indication for onabotulinum toxin A (Botox, Actavis) for the treatment of adults with upper limb spasticity, according to a company news release.

The expanded i"...



Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)



Usage in Pregnancy: Safety for use in pregnancy has not been established.

The administration of troleandomycin has been associated with an allergic type of cholestatic hepatitis. Some patients receiving troleandomycin for more than two weeks or in repeated courses have shown jaundice accompanied by right upper quadrant pain, fever, nausea, vomiting, eosinophilia, and leukocytosis. These changes have been reversible on discontinuance of the drug. Liver function tests should be monitored in patients on such dosage, and the drug discontinued if abnormalities develop. Reports in the literature have suggested that the concurrent use of ergotamine-containing drugs and troleandomycin may induce ischemic reactions. Therefore, the concurrent use of ergotamine-containing drugs and troleandomycin should be avoided. Troleandomycin should be administered with caution to patients concurrently receiving estrogen containing oral contraceptives.

Studies in chronic asthmatic patients have suggested that the concurrent use of theophylline and troleandomycin may result in elevated serum concentrations of theophylline. Therefore, it is recommended that patients receiving such concurrent therapy be observed for signs of theophylline toxicity, and that therapy be appropriately modified if such signs develop.



Troleandomycin is principally excreted by the liver.

Caution should be exercised in administering the antibiotic to patients with impaired hepatic function.

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 12/8/2004


Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Women's Health

Find out what women really need.