"Vemurafenib (Zelboraf, Roche/Genentech), a BRAF inhibitor marketed for use in the treatment of melanoma, has now shown activity in patients with refractory papillary thyroid cancer.
For the approximately 25% to 50% of patients "...
(methimazole) Tablets , USP
TAPAZOLE® (Methimazole Tablets, USP) (1-methylimidazole-2-thiol) is a white, crystalline substance that is freely soluble in water. It differs chemically from the drugs of the thiouracil series primarily because it has a 5- instead of a 6-membered ring.
Each tablet contains 5 or 10 mg (43.8 or 87.6 μmol) methimazole, an orally administered antithyroid drug.
Each tablet also contains lactose monohydrate, magnesium stearate, starch (corn), pregelatinized starch and talc.
The molecular weight is 114.16, and the molecular formula is C4H6N2S. The structural formula is as follows:
What are the possible side effects of methimazole (Northyx, Tapazole)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using methimazole and call your doctor at once if you have a serious side effect such as:
- fever, chills, sore throat, body aches, flu symptoms;
- easy bruising or bleeding, unusual weakness;
- blood in your urine or stools;
- severe blistering, peeling, and red skin rash; or
- nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice...
What are the precautions when taking methimazole (Tapazole)?
Before taking methimazole, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood disorders (such as agranulocytosis, thrombocytopenia), liver disease.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
This medication is not recommended for use during the first 3 months of pregnancy. It should be used only when clearly needed during the last 6 months of pregnancy. Discuss the...
Last reviewed on RxList: 9/6/2016
This monograph has been modified to include the generic and brand name in many instances.
Additional Tapazole Information
Tapazole - User Reviews
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