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Single oral doses of TARCEVA up to 1,000 mg in healthy subjects and weekly doses up to 1,600 mg in cancer patients have been tolerated. Repeated twice-daily doses of 200 mg single-agent TARCEVA in healthy subjects were poorly tolerated after only a few days of dosing. Based on the data from these studies, an unacceptable incidence of severe adverse reactions, such as diarrhea, rash, and liver transaminase elevation, may occur above the recommended dose [see DOSAGE AND ADMINISTRATION]. In case of suspected overdose, TARCEVA should be withheld and symptomatic treatment instituted.
Last reviewed on RxList: 4/28/2014
This monograph has been modified to include the generic and brand name in many instances.
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