Targretin (Bexarotene) Patient Information: Missed a Dose and What Should I Avoid at RxList

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May 27, 2012

Targretin

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Targretin

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Targretin Patient Information including If I Miss a Dose

What happens if I miss a dose (Targretin)?

Take the missed dose, with food, as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose (Targretin)?

Seek emergency medical attention.

Symptoms of a bexarotene overdose are unknown.

What should I avoid while using bexarotene (Targretin)?

Avoid prolonged exposure to sunlight or artificial ultraviolet light (e.g. sunlamps). Bexarotene may increase the sensitivity of your skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable.

Vitamin A may increase side effects when taking bexarotene. Limit your use of vitamin A supplements to not more than the recommended daily allowance (RDA) of 4000 to 5000 International Units (IU) a day. If you take vitamins, check the label to see how much vitamin A they contain. If you are not sure, ask your doctor or pharmacist.

Grapefruit and grapefruit juice may interact with bexarotene. The interaction could have potentially dangerous effects. Discuss the use of grapefruit and grapefruit juice with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

What other drugs will affect bexarotene (Targretin)?

Do not take bexarotene without first talking to your doctor if you are taking any of the following drugs:

gemfibrozil (Lopid);
ketoconazole (Nizoral) or itraconazole (Sporanox);
erythromycin (E.E.S., E-Mycin, Eryc, Ery-Tab, Ilosone, others);
rifampin (Rifadin, Rimactane);
phenobarbital (Luminal, Solfoton);
phenytoin (Dilantin, others); or
a diabetes medicine such as insulin, glipizide (Glucotrol), glyburide (Diabeta, Micronase, Glynase), chlorpropamide (Diabinese), tolbutamide (Orinase), tolazamide (Tolinase), glimepiride (Amaryl), rosiglitazone (Avandia), pioglitazone (Actos), metformin (Glucophage), and others.

You may not be able to take bexarotene, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with bexarotene. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

Your pharmacist has additional information about bexarotene written for health professionals that you may read.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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