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Targretin Gel

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Since 2009, the Food and Drug Administratio"...

Targretin Gel

Targretin®
(bexarotene) 1% Gel

Targretin Gel

DRUG DESCRIPTION

Targretin® (bexarotene) gel 1% contains bexarotene and is intended for topical application only. Bexarotene is a member of a subclass of retinoids that selectively activate retinoid X receptors (RXRs). These retinoid receptors have biologic activity distinct from that of retinoic acid receptors (RARs).

The chemical name is 4-[1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl2-naphthalenyl)ethenyl] benzoic acid, and the structural formula is as follows:

  Targretin® (bexarotene)  Structural Formula Illustration

Bexarotene is an off-white to white powder with a molecular weight of 348.48 and a molecular formula of C24H28O2. It is insoluble in water and slightly soluble in vegetable oils and ethanol, USP.

Targretin® gel is a clear gelled solution containing 1.0% (w/w) bexarotene in a base of dehydrated alcohol, USP, polyethylene glycol 400, NF, hydroxypropyl cellulose, NF, and butylated hydroxytoluene, NF.

What are the possible side effects of bexarotene topical (Targretin Topical)?

Serious side effects are not likely to occur. Stop using bexarotene topical and seek emergency medical attention if you experience an allergic reaction (shortness of breath; closing of your throat; swelling of your lips, face, or tongue; or hives).

You may experience some redness, itching, warmth, swelling, burning, scaling, or other irritation while you are using bexarotene topical. If these side effects are excessive, talk to your doctor. Your doctor may prescribe less frequent applications of bexarotene topical.

Side effects other than those listed here may...

Read All Potential Side Effects and See Pictures of Targretin Gel »

Last reviewed on RxList: 6/2/2011
This monograph has been modified to include the generic and brand name in many instances.

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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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