Targretin Gel
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Targretin Gel
Targretin®
(bexarotene) 1% Gel
DRUG DESCRIPTION
Targretin® (bexarotene) gel 1% contains bexarotene and is intended for topical application only. Bexarotene is a member of a subclass of retinoids that selectively activate retinoid X receptors (RXRs). These retinoid receptors have biologic activity distinct from that of retinoic acid receptors (RARs).
The chemical name is 4-[1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl2-naphthalenyl)ethenyl] benzoic acid, and the structural formula is as follows:
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Bexarotene is an off-white to white powder with a molecular weight of 348.48 and a molecular formula of C24H28O2. It is insoluble in water and slightly soluble in vegetable oils and ethanol, USP.
Targretin® gel is a clear gelled solution containing 1.0% (w/w) bexarotene in a base of dehydrated alcohol, USP, polyethylene glycol 400, NF, hydroxypropyl cellulose, NF, and butylated hydroxytoluene, NF.
Last reviewed on RxList: 6/2/2011
This monograph has been modified to include the generic and brand name in many instances.
Additional Targretin Gel Information
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