In this Article

• What is trandolapril and verapamil (Tarka)?
• What are the possible side effects of trandolapril and verapamil (Tarka)?
• What is the most important information I should know about trandolapril and verapamil (Tarka)?
• What should I discuss with my healthcare provider before taking trandolapril and verapamil (Tarka)?
• How should I take trandolapril and verapamil (Tarka)?
• What happens if I miss a dose (Tarka)?
• What happens if I overdose (Tarka)?
• What should I avoid while taking trandolapril and verapamil (Tarka)?
• What other drugs will affect trandolapril and verapamil (Tarka)?
• Where can I get more information?

What should I discuss with my healthcare provider before taking trandolapril and verapamil (Tarka)?

You should not use this medicine if you are allergic to trandolapril (Mavik) or verapamil (Calan, Covera, Isoptin, Verelan), or if you have:

• certain serious heart conditions, especially "sick sinus syndrome" or "AV block" (unless you have a pacemaker);
• a heart rhythm disorder;
• low blood pressure; or
• if you are allergic to any other ACE inhibitor, such as benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), or ramipril (Altace).

To make sure you can safely take trandolapril and verapamil, tell your doctor if you have any of these other conditions:

• kidney disease (or if you are on dialysis);
• liver disease;
• congestive heart failure;
• diabetes;
• a nerve-muscle disease such as muscular dystrophy; or
• a connective tissue disease such as Marfan syndrome, Sjogren's syndrome, lupus, scleroderma, or rheumatoid arthritis.

FDA pregnancy category D. Do not use trandolapril and verapamil if you are pregnant. Stop using this medication and tell your doctor right away if you become pregnant. Trandolapril and verapamil can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control while taking trandolapril and verapamil.

Trandolapril and verapamil can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using trandolapril and verapamil.

How should I take trandolapril and verapamil (Tarka)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results.

Trandolapril and verapamil works best if you take it with food.

Your blood pressure will need to be checked often. Visit your doctor regularly.

Conditions that may cause very low blood pressure include: vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low salt diet, or taking diuretics (water pills). Follow your doctor's instructions about the type and amount of liquids you should drink while taking trandolapril and verapamil. Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting.

If you need surgery, tell the surgeon ahead of time that you are using trandolapril and verapamil.

Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Store at room temperature away from moisture and heat.