Teflaro (Ceftaroline Fosamil Injection for Intravenous (IV) Use) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 27, 2012

Teflaro

Staph Infection (Staphylococcus Aureus) »

What is Staphylococcus?

Staphylococcus is a group of bacteria that can cause a number of diseases as a result of infection of various tissues of the body. Staphylococcus is more familiarly known as Staph (pronounced "staff"). Staph-related illness can range from mild and requiring no treatment to severe and potentially fatal.

The name Staphylococcus comes from the Greek staphyle, meaning a bunch of grapes, and kokkos, meaning berry, and that is what Staph bacteria look like under the microscope, like a bunch of grapes or little round berries. (In technical terms, these are gram-positive, facultative anaerobic, usually unencapsulated cocci.)

Over 30 different types of Staphylococci can infect humans, but most infections are caused by Staphylococcus aureus. Staphylococci can be found normally in the nose and on the skin (and less commonly in other locations) of around 25%-30% of healthy adults and...

Read the Staph Infection (Staphylococcus Aureus) article »

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TEFLARO®
(ceftaroline fosamil) Injection for Intravenous (IV) Use

DRUG DESCRIPTION

Teflaro is a sterile, semi-synthetic, broad-spectrum, prodrug antibacterial of cephalosporin class of beta-lactams (β-lactams). Chemically, the prodrug, ceftaroline fosamil monoacetate monohydrate is (6R,7R)-7-{(2Z)-2-(ethoxyimino)-2-[5-(phosphonoamino)-l,2,4-thiadiazol-3-yl]acetamido}-3-{[4-(l-methylpyridin-l-ium-4-yl)-l,3-thiazol-2-yl]sulfanyl}-8-oxo-5-thia-l-azabicyclo[4.2.0]oct-2-ene-2-carboxylate monoacetate monohydrate. Its molecular weight is 762.75. The empirical formula is C₂₂H₂₁N₈O₈PS₄.C₂H₄O₂.H₂O.

Figure 1: Chemical structure of ceftaroline fosamil

Teflaro
(ceftaroline fosamil) structural formula Illustration

Teflaro vials contain either 600 mg or 400 mg of anhydrous ceftaroline fosamil. The powder for injection is formulated from ceftaroline fosamil monoacetate monohydrate, a pale yellowish-white to light yellow sterile powder. All references to ceftaroline activity are expressed in terms of the prodrug, ceftaroline fosamil. The powder is constituted for IV injection [see DOSAGE AND ADMINISTRATION].

Each vial of Teflaro contains ceftaroline fosamil and L-arginine, which results in a constituted solution at pH 4.8 to 6.5.

What are the precautions when taking ceftaroline fosamil injection for intravenous (iv) use (Teflaro)?

Before taking this product, tell your doctor or pharmacist if you are allergic to either aliskiren or amlodipine; or to other calcium channel blockers (such as nifedipine); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Too much sweating, diarrhea, or vomiting may cause loss of too much body water (dehydration) and increase your risk of lightheadedness. Report prolonged...

Read All Potential Precautions of Teflaro »

Last reviewed on RxList: 5/21/2012
This monograph has been modified to include the generic and brand name in many instances.