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(aliskiren) Tablets, for Oral Use
WARNING: FETAL TOXICITY
Tekturna contains aliskiren hemifumarate, a renin inhibitor, that is provided as tablets for oral administration. Aliskiren hemifumarate is chemically described as (2S,4S,5S,7S)-N-(2-carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3-methoxypropoxy)phenyl]-octanamide hemifumarate and its structural formula is
Molecular formula: C30H53N3O6·0.5 C4H4O4
Aliskiren hemifumarate is a white to slightly yellowish crystalline powder with a molecular weight of 609.8 (free base-551.8). It is soluble in phosphate buffer, n-octanol, and highly soluble in water.
What are the possible side effects of aliskiren (Tekturna)?
Stop taking aliskiren and get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat.
If you have an allergic reaction to aliskiren you should not take it again.
Call your doctor at once if you have a serious side effect such as:
- feeling light-headed, fainting;
- nausea with slow uneven heart rate and a weak pulse; or
- swelling around your eyes.
Less serious side effects may include:
- stomach pain or...
What are the precautions when taking aliskiren tablets (Tekturna)?
Before taking aliskiren, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: diabetes, gout, heart problems, kidney disease (including kidney stones), loss of too much body water (dehydration), untreated mineral imbalance (such as low sodium, high potassium).
Before having surgery, tell your doctor or dentist that you are taking this medication.
This medication is not recommended for use during pregnancy due to the risk for harm to an unborn baby. Consult your doctor for more details....
Last reviewed on RxList: 5/2/2012
This monograph has been modified to include the generic and brand name in many instances.
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