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Tekturna

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Tekturna

Tekturna®
(aliskiren) Tablets for Oral Administration

WARNING

FETAL TOXICITY

  • When pregnancy is detected, discontinue Tekturna as soon as possible.
  • Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.

DRUG DESCRIPTION

Tekturna contains aliskiren hemifumarate, a renin inhibitor, that is provided as tablets for oral administration. Aliskiren hemifumarate is chemically described as (2S,4S,5S,7S)-N-(2-carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7diisopropyl-8-[4-methoxy-3-(3-methoxypropoxy)phenyl]-octanamide hemifumarate and its structural formula is

Tekturna® (aliskiren) Structural Formula Illustration

Molecular formula: C30H53N3O6 •0.5 C4H4O4

Aliskiren hemifumarate is a white to slightly yellowish crystalline powder with a molecular weight of 609.8 (free base- 551.8). It is soluble in phosphate buffer, n-octanol, and highly soluble in water.

What are the possible side effects of aliskiren (Tekturna)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficult breathing; swelling of your face, lips, tongue, or throat.

If you have an allergic reaction to aliskiren you should not take it again.

Call your doctor at once if you have a serious side effect such as:

  • feeling light-headed, fainting;
  • nausea with slow uneven heart rate and a weak pulse;
  • swelling around your eyes; or
  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes,...

Read All Potential Side Effects and See Pictures of Tekturna »

What are the precautions when taking aliskiren tablets (Tekturna)?

Before taking aliskiren, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: diabetes, gout, heart problems, kidney disease (including kidney stones), loss of too much body water (dehydration), untreated mineral imbalance (such as low sodium, high potassium).

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

This medication may increase your potassium...

Read All Potential Precautions of Tekturna »

Last reviewed on RxList: 4/7/2014
This monograph has been modified to include the generic and brand name in many instances.

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Tekturna - User Reviews

Tekturna User Reviews

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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