Temovate Gel (Clobetasol Propionate Gel) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 10, 2012

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Temovate Gel User Reviews >>

Temovate Gel

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TEMOVATE®
(clobetasol propionate) Gel, 0.05%

FOR TOPICAL DERMATOLOGIC USE ONLY
NOT FOR OPHTHALMIC, ORAL, OR INTRA VAGINAL USE

DRUG DESCRIPTION

TEMOVATE (clobetasol propionate gel) Gel contains the active compound clobetasol propionate, a synthetic corticosteroid, for topical dermatologic use. Clobetasol, an analog of prednisolone, has a high degree of glucocorticoid activity and a slight degree of mineratocorticoid activity.

Chemically, clobetasol propionate is (118,168)- 21 -chforo-9-fluoro-11 -hydroxy-16-methyl-17- (1 -oxopropoxy)-pregna-1,4-diene-3,20-dione, and it has the following structural formula:

TEMOVATE (clobetasol propionate) structural formula illustration

Clobetasol propionate has the empirical formula C₂₅H₃₂CIFO₅ and a molecular weight of 467. It is a white to cream-colored crystalline powder insoluble in water.

TEMOVATE Gel contains clobetasol propionate 0.5 mg/g in a base of propylene glycol, carbomer 934P, sodium hydroxide, and purified water.

What are the possible side effects of clobetasol topical?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have severe irritation of any treated skin, or if you show signs of absorbing clobetasol topical through your skin, such as:

blurred vision, or seeing halos around lights;
mood changes;
sleep problems (insomnia);
weight gain, puffiness in your face; or
muscle...

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What are the precautions when taking clobetasol propionate gel (Temovate Gel)?

Before using clobetasol, tell your doctor or pharmacist if you are allergic to it; or to other corticosteroids (e.g., hydrocortisone, prednisone); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: poor blood circulation, immune system problems, certain skin conditions (rosacea, perioral dermatitis).

Do not use if there is an infection or sore present in the area to be treated.

Rarely, using corticosteroid medications for a long time or over large areas of skin can make it more difficult for your body to respond to physical stress. Therefore,...

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Last reviewed on RxList: 3/24/2008
This monograph has been modified to include the generic and brand name in many instances.