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Signs and Symptoms
A 25-year-old female intentionally ingested 60 mg. She presented with severe drowsiness and bradycardia of 45 beats/minute. Gastric lavage was performed and an infusion of isoproterenol (0.8 mg in 12 hours) was administered. She recovered quickly and without sequelae.
A 2-year-old male weighing 12 kg who ingested up to 4 mg of guanfacine developed lethargy. Gastric lavage (followed by activated charcoal and sorbitol slurry via NG tube) removed some tablet fragments within 2 hours after ingestion, and vital signs were normal.
Treatment of Overdosage
Gastric lavage and supportive therapy as appropriate. Guanfacine is not dialyzable in clinically significant amounts (2.4%).
Tenex is contraindicated in patients with known hypersensitivity to guanfacine hydrochloride.This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 7/18/2013
Additional Tenex Information
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