Tenoretic (Atenolol and Chlorthalidone) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

Tenoretic

High Blood Pressure »

High blood pressure facts

High blood pressure (hypertension) is designated as either essential (primary) hypertension or secondary hypertension and is defined as a consistently elevated blood pressure exceeding 140/90 mm Hg.
High blood pressure is called "the silent killer" because it often causes no symptoms for many years, even decades, until it finally damages certain critical organs.
Poorly controlled high blood pressure ultimately can cause damage to blood vessels in the eye, thickening of the heart muscle and heart attacks, hardening of the arteries (arteriosclerosis), kidney failure, and strokes.
Most antihypertensive medications can be used alone or in combination. Some are used only in combination. Some are preferred over others in certain specific medical situations. And some are not to be used (contraindicated) in other situations.
Several classes of antihypertensive medications are available, including ACE i...

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Tenoretic

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TENORETIC
(atenolol and chlorthalidone)

DRUG DESCRIPTION

TENORETIC® (atenolol and chlorthalidone) is for the treatment of hypertension. It combines the antihypertensive activity of two agents: a beta₁-selective (cardioselective) hydrophilic blocking agent (atenolol, TENORMIN®) and a monosulfonamyl diuretic (chlorthalidone). Atenolol is Benzeneacetamide, 4-[2'-hydroxy-3'-[(1-methylethyl) amino] propoxy]-.

Atenolol structural formula illustration

Atenolol (free base) is a relatively polar hydrophilic compound with a water solubility of 26.5 mg/mL at 37° C. It is freely soluble in 1N HCl (300 mg/mL at 25°C) and less soluble in chloroform (3 mg/mL at 25°C).

Chlorthalidone is 2-Chloro-5-(1-hydroxy-3-oxo-1- isoindolinyl) benzene sulfonamide:

Chlorthalidone structural formula illustration

Chlorthalidone has a water solubility of 12 mg/100 mL at 20°C.

Each TENORETIC (atenolol and chlorthalidone) 100 Tablet contains:

Atenolol (TENORMIN®).......................................100 mg
Chlorthalidone........................................................25 mg

Each TENORETIC (atenolol and chlorthalidone) 50 Tablet contains:

Atenolol (TENORMIN®).........................................50 mg
Chlorthalidone..........................................................25 mg

Inactive ingredients: magnesium stearate, microcrystalline cellulose, povidone, sodium starch glycolate.

What are the possible side effects of atenolol and chlorthalidone (Tenoretic 100, Tenoretic 50)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
slow or uneven heartbeats;
feeling like you might pass out;
feeling short of breath, even with mild exertion;

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What are the precautions when taking atenolol and chlorthalidone (Tenoretic)?

Before taking this product, tell your doctor or pharmacist if you are allergic to atenolol or chlorthalidone; or to thiazide diuretics (such as hydrochlorothiazide); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: certain types of heart rhythm problems (such as a slow heartbeat, second- or third-degree atrioventricular block, sick sinus syndrome), an inability to make urine (anuria).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood circulation...

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Last reviewed on RxList: 1/8/2009
This monograph has been modified to include the generic and brand name in many instances.