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Tenoretic

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Tenoretic

TENORETIC
(atenolol and chlorthalidone)

Tenoretic

DRUG DESCRIPTION

TENORETIC® (atenolol and chlorthalidone) is for the treatment of hypertension. It combines the antihypertensive activity of two agents: a beta1-selective (cardioselective) hydrophilic blocking agent (atenolol, TENORMIN®) and a monosulfonamyl diuretic (chlorthalidone). Atenolol is Benzeneacetamide, 4-[2'-hydroxy-3'-[(1-methylethyl) amino] propoxy]-.

Atenolol structural formula illustration

Atenolol (free base) is a relatively polar hydrophilic compound with a water solubility of 26.5 mg/mL at 37° C. It is freely soluble in 1N HCl (300 mg/mL at 25°C) and less soluble in chloroform (3 mg/mL at 25°C).

Chlorthalidone is 2-Chloro-5-(1-hydroxy-3-oxo-1- isoindolinyl) benzene sulfonamide:

Chlorthalidone structural formula illustration

Chlorthalidone has a water solubility of 12 mg/100 mL at 20°C.

Each TENORETIC (atenolol and chlorthalidone) 100 Tablet contains:

Atenolol (TENORMIN®).......................................100 mg
Chlorthalidone........................................................25 mg

Each TENORETIC (atenolol and chlorthalidone) 50 Tablet contains:

Atenolol (TENORMIN®).........................................50 mg
Chlorthalidone..........................................................25 mg

Inactive ingredients: magnesium stearate, microcrystalline cellulose, povidone, sodium starch glycolate.

What are the possible side effects of atenolol and chlorthalidone (Tenoretic 100, Tenoretic 50)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
  • fast, slow, or uneven heartbeats;
  • feeling like you might pass out;
  • feeling short of breath, even with mild exertion;
  • swelling, rapid weight gain;
  • pale skin, easy...

Read All Potential Side Effects and See Pictures of Tenoretic »

What are the precautions when taking atenolol and chlorthalidone (Tenoretic)?

Before taking this product, tell your doctor or pharmacist if you are allergic to atenolol or chlorthalidone; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, certain types of heart rhythm problems (such as a slow heartbeat, second- or third-degree atrioventricular block), gout, lupus, breathing problems (such as asthma, chronic bronchitis, emphysema), blood circulation problems (such as Raynaud's disease, peripheral vascular disease), untreated mineral imbalance (such as low potassium), serious allergic reactions including...

Read All Potential Precautions of Tenoretic »

Last reviewed on RxList: 1/8/2009
This monograph has been modified to include the generic and brand name in many instances.

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Tenoretic - User Reviews

Tenoretic User Reviews

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Here is a collection of user reviews for the medication Tenoretic sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Hypertension

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