Tenoretic (Atenolol and Chlorthalidone) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 9, 2012

Tenoretic

High Blood Pressure »

What is high blood pressure?

High blood pressure (HBP) or hypertension means high pressure (tension) in the arteries. Arteries are vessels that carry blood from the pumping heart to all the tissues and organs of the body. High blood pressure does not mean excessive emotional tension, although emotional tension and stress can temporarily increase blood pressure. Normal blood pressure is below 120/80; blood pressure between 120/80 and 139/89 is called "pre-hypertension", and a blood pressure of 140/90 or above is considered high.

The top number, the systolic blood pressure, corresponds to the pressure in the arteries as the heart contracts and pumps blood forward into the arteries. The bottom number, the diastolic pressure, represents the pressure in the arteries as the heart relaxes after the contraction. The diastolic pressure reflects the lowest pressure to which the arteries are exposed.

An elevation of the systolic and/or diastolic blood pressure increas...

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Tenoretic

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TENORETIC
(atenolol and chlorthalidone)

DRUG DESCRIPTION

TENORETIC® (atenolol and chlorthalidone) is for the treatment of hypertension. It combines the antihypertensive activity of two agents: a beta₁-selective (cardioselective) hydrophilic blocking agent (atenolol, TENORMIN®) and a monosulfonamyl diuretic (chlorthalidone). Atenolol is Benzeneacetamide, 4-[2'-hydroxy-3'-[(1-methylethyl) amino] propoxy]-.

Atenolol structural formula illustration

Atenolol (free base) is a relatively polar hydrophilic compound with a water solubility of 26.5 mg/mL at 37° C. It is freely soluble in 1N HCl (300 mg/mL at 25°C) and less soluble in chloroform (3 mg/mL at 25°C).

Chlorthalidone is 2-Chloro-5-(1-hydroxy-3-oxo-1- isoindolinyl) benzene sulfonamide:

Chlorthalidone structural formula illustration

Chlorthalidone has a water solubility of 12 mg/100 mL at 20°C.

Each TENORETIC (atenolol and chlorthalidone) 100 Tablet contains:

Atenolol (TENORMIN®).......................................100 mg
Chlorthalidone........................................................25 mg

Each TENORETIC (atenolol and chlorthalidone) 50 Tablet contains:

Atenolol (TENORMIN®).........................................50 mg
Chlorthalidone..........................................................25 mg

Inactive ingredients: magnesium stearate, microcrystalline cellulose, povidone, sodium starch glycolate.

What are the possible side effects of atenolol and chlorthalidone (Tenoretic 100, Tenoretic 50)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
slow or uneven heartbeats;
feeling like you might pass out;
feeling short of breath, even with mild exertion;

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What are the precautions when taking atenolol and chlorthalidone (Tenoretic)?

Before taking this product, tell your doctor or pharmacist if you are allergic to atenolol or chlorthalidone; or to thiazide diuretics (such as hydrochlorothiazide); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: certain types of heart rhythm problems (such as a slow heartbeat, second- or third-degree atrioventricular block, sick sinus syndrome), an inability to make urine (anuria).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood circulation...

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Last reviewed on RxList: 1/8/2009
This monograph has been modified to include the generic and brand name in many instances.