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Tenoretic Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Tenoretic (atenolol and chlorthalidone) is used to treat hypertension (high blood pressure). Atenolol is a beta-blocker and chlorthalidone is a thiazide diuretic (water pill). This medication is available in generic form. Common side effects include dizziness, lightheadedness, slow heartbeat, tiredness, nausea, and diarrhea.
The initial dose is one Tenoretic 50 tablet once a day. If an optimal response is not achieved, the dosage should be increased to one Tenoretic 100 tablet once a day. Tenoretic may interact with other blood pressure medications, dobutamine, indomethacin, isoproterenol, lithium, diabetes medication, diuretics (water pills), or steroids. Tell your doctor all medications you use. During pregnancy, Tenoretic should be used only when prescribed. It may harm a fetus. Atenolol and chlorthalidone pass into breast milk. Atenolol may have undesirable effects on a nursing infant. Discuss the risks and benefits with your doctor before breast-feeding.
Our Tenoretic (atenolol and chlorthalidone) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Tenoretic in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
- fast, slow, or uneven heartbeats;
- feeling like you might pass out;
- feeling short of breath, even with mild exertion;
- swelling, rapid weight gain;
- pale skin, easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin, trouble concentrating;
- confusion, hallucinations, seizure (convulsions);
- cold feeling in your hands and feet;
- nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
- dry mouth, extreme thirst, drowsiness, restless feeling, nausea, vomiting, increased urination, leg discomfort, muscle pain or weakness, fainting; or
- memory problems, weakness, loss of appetite, feeling unsteady, shallow breathing or breathing that stops.
Less serious side effects may include:
- dizziness, spinning sensation;
- tired feeling;
- diarrhea, constipation, upset stomach;
- mild itching or skin rash; or
- impotence, loss of interest in sex, or trouble having an orgasm.
Read the entire detailed patient monograph for Tenoretic (Atenolol and Chlorthalidone) »
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Tenoretic Overview - Patient Information: Side Effects
Dizziness, lightheadedness, tiredness, nausea, and diarrhea may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.
This product may reduce blood flow to your hands and feet, causing them to feel cold. Smoking may worsen this effect. Dress warmly and avoid tobacco use.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
The chlorthalidone in this product may cause a loss of too much body water (dehydration) and salt/minerals. Tell your doctor right away if you have any symptoms of dehydration or mineral loss, including: extreme thirst, very dry mouth, muscle cramps, weakness, fast/irregular heartbeat, confusion.
Tell your doctor right away if you have any serious side effects, including: very slow heartbeat, fainting, trouble breathing, change in the amount of urine (not including the normal increase in urine when you first start this drug), toe/joint pain, mental/mood changes (such as depression, mood swings), blue fingers/toes, new or worsening symptoms of heart failure (such as swelling ankles/feet, severe tiredness, shortness of breath, unexplained/sudden weight gain).
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Tenoretic (Atenolol and Chlorthalidone)»
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Tenoretic FDA Prescribing Information: Side Effects
TENORETIC (atenolol and chlorthalidone) is usually well tolerated in properly selected patients. Most adverse effects have been mild and transient.The adverse effects observed for TENORETIC (atenolol and chlorthalidone) are essentially the same as those seen with the individual components.
The frequency estimates in the following table were derived from controlled studies in which adverse reactions were either volunteered by the patient (US studies) or elicited, eg, by checklist (foreign studies). The reported frequency of elicited adverse effects was higher for both atenolol and placebo treated patients than when these reactions were volunteered. Where frequency of adverse effects for atenolol and placebo is similar, causal relationship to atenolol is uncertain.
|Volunteered (US Studies)||Total-Volunteered and Elicited (Foreign + US Studies)|
(n = 164)
(n = 206)
(n = 399)
(n = 407)
|CENTRAL NERVOUS SYSTEM/ NEUROMUSCULAR|
|RESPIRATORY (see WARNINGS)|
During postmarketing experience, the following have been reported in temporal relationship to the use of the drug: elevated liver enzymes and/or bilirubin, hallucinations, headache, impotence, Peyronie's disease, postural hypotension which may be associated with syncope, psoriasiform rash or exacerbation of psoriasis, psychoses, purpura, reversible alopecia, thrombocytopenia, visual disturbance, sick sinus syndrome, and dry mouth. TENORETIC (atenolol and chlorthalidone) , like other beta blockers, has been associated with the development of antinuclear antibodies (ANA), lupus syndrome, and Raynaud's
Cardiovascular: orthostatic hypotension; Gastrointestinal: anorexia, gastric irritation, vomiting, cramping, constipation, jaundice (intrahepatic cholestatic jaundice), pancreatitis; CNS: vertigo, paresthesia, xanthopsia; Hematologic: leukopenia, agranulocytosis, thrombocytopenia, aplastic anemia; Hypersensitivity: purpura, photosensitivity, rash, urticaria, necrotizing angiitis (vasculitis) (cutaneous vasculitis), Lyell's syndrome (toxic epidermal necrolysis); Miscellaneous: hyperglycemia, glycosuria, hyperuricemia, muscle spasm, weakness, restlessness. Clinical trials of TENORETIC (atenolol and chlorthalidone) conducted in the United States (89 patients treated with TENORETIC (atenolol and chlorthalidone) ) revealed no new or unexpected adverse effects.
Potential Adverse Effects
In addition, a variety of adverse effects not observed in clinical trials with atenolol but reported with other beta-adrenergic blocking agents should be considered potential adverse effects of atenolol. Nervous System: Reversible mental depression progressing to catatonia; an acute reversible syndrome characterized by disorientation for time and place, short-term memory loss, emotional lability, slightly clouded sensorium, decreased performance on neuropsychometrics; Cardiovascular: Intensification of AV block (see CONTRAINDICATIONS); Gastrointestinal: Mesenteric arterial thrombosis, ischemic colitis; Hematologic: Agranulocytosis; Allergic: Erythematous rash, fevercombined with aching and sore throat, laryngospasm and respiratory distress.
There have been reports of skin rashes and/or dry eyes associated with the use of beta-adrenergic blocking drugs. The reported incidence is small, and, in most cases, the symptoms have cleared when treatment was withdrawn. Discontinuance of the drug should be considered if any such reaction is not otherwise explicable. Patients should be closely monitored following cessation of therapy. (See DOSAGE AND ADMINISTRATION.)
The oculomucocutaneous syndrome associated with the beta blocker practolol has not been reported with atenolol (TENORMIN). Furthermore, a number of patients who had previously demonstrated established practolol reactions were transferred to atenolol (TENORMIN) therapy with subsequent resolution or quiescence of the reaction.
Clinical Laboratory Test Findings
Clinically important changes in standard laboratory parameters were rarely associated with the administration of TENORETIC (atenolol and chlorthalidone) . The changes in laboratory parameters were notprogressive and usually were not associated with clinical manifestations. The most common changes were increases inuric acid and decreases in serum potassium.
Read the entire FDA prescribing information for Tenoretic (Atenolol and Chlorthalidone) »
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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