Tenormin I.V. Injection (Atenolol Inj) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

Tenormin IV Injection

Raynaud's Phenomenon »

What is Raynaud's phenomenon?

Raynaud's phenomenon (RP) is a condition resulting in a particular series of discolorations of the fingers and/or the toes after exposure to changes in temperature (cold or hot) or emotional events. Skin discoloration occurs because an abnormal spasm of the blood vessels causes a diminished blood supply to the local tissues. Initially, the digit(s) involved turn white because of the diminished blood supply. The digit(s) then turn blue because of prolonged lack of oxygen. Finally, the blood vessels reopen, causing a local "flushing" phenomenon, which turns the digit(s) red. This three-phase color sequence (white to blue to red), most often upon exposure to cold temperature, is characteristic of RP.

Raynaud's phenomenon most frequently affects women, especially in the second, third, or fourth decades of life. People can have Raynauds phenomenon alone or as a part of other rheumatic diseases. When it occurs alone...

Read the Raynaud's Phenomenon article »

Tenormin I.V. Injection

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Please Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

TENORMIN®
(atenolol) I.V. Injection

DRUG DESCRIPTION

TENORMIN® (atenolol), a synthetic, beta₁-selective (cardioselective) adrenoreceptor blocking agent, may be chemically described as benzeneacetamide, 4-[2'-hydroxy-3'- [(1 methylethyl)amino]propoxy]-. The molecular and structural formulas are:

C₁₄H₂₂N₂O₃

Atenolol (free base) has a molecular weight of 266. It is a relatively polar hydrophilic compound with a water solubility of 26.5 mg/mL at 37°C and a log partition coefficient (octanol/water) of 0.23. It is freely soluble in 1N HCl (300 mg/mL at 25°C) and less soluble in chloroform (3 mg/mL at 25°C).

TENORMIN for parenteral administration is available as TENORMIN I.V. Injection containing 5 mg atenolol in 10 mL sterile, isotonic, citrate-buffered, aqueous solution. The pH of the solution is 5.5-6.5.

Inactive Ingredients: Sodium chloride for isotonicity and citric acid and sodium hydroxide to adjust pH.

Last reviewed on RxList: 9/10/2005
This monograph has been modified to include the generic and brand name in many instances.