Tenormin I.V. Injection (Atenolol Inj) Patient Information: Side Effects and Drug Images at RxList

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May 27, 2012

Tenormin IV Injection

Atrial Fibrillation »

What is atrial fibrillation?

Atrial fibrillation (AF) is the most common, abnormal rhythm of the heart.

The heart contracts (beats) and pumps blood with a regular rhythm, for example, at a rate of 60 beats per minute there is a beat every second. The heart may beat faster or slower with a shorter or longer interval between beats, but at any one rate the interval between beats is constant. This regular rhythm occurs as a result of regular electrical discharges (currents) that travel through the heart and cause the muscle of the heart to contract. In atrial fibrillation, the electrical discharges are irregular and rapid and, as a result, the heart beats irregularly and, usually, rapidly.

Atrial fibrillation is common; half a million new cases are diagnosed yearly in the U.S., and billions of dollars are spent annually on its diagnosis and treatment.

What causes atrial fibrillation?

Normal function of the he...

Read the Atrial Fibrillation article »

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Please Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

TENORMIN®
(atenolol) I.V. Injection

DRUG DESCRIPTION

TENORMIN® (atenolol), a synthetic, beta₁-selective (cardioselective) adrenoreceptor blocking agent, may be chemically described as benzeneacetamide, 4-[2'-hydroxy-3'- [(1 methylethyl)amino]propoxy]-. The molecular and structural formulas are:

C₁₄H₂₂N₂O₃

Atenolol (free base) has a molecular weight of 266. It is a relatively polar hydrophilic compound with a water solubility of 26.5 mg/mL at 37°C and a log partition coefficient (octanol/water) of 0.23. It is freely soluble in 1N HCl (300 mg/mL at 25°C) and less soluble in chloroform (3 mg/mL at 25°C).

TENORMIN for parenteral administration is available as TENORMIN I.V. Injection containing 5 mg atenolol in 10 mL sterile, isotonic, citrate-buffered, aqueous solution. The pH of the solution is 5.5-6.5.

Inactive Ingredients: Sodium chloride for isotonicity and citric acid and sodium hydroxide to adjust pH.

Last reviewed on RxList: 9/10/2005
This monograph has been modified to include the generic and brand name in many instances.