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Tequin

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Tequin

TEQUIN®
(gatifloxacin) Tablets
(gatifloxacin) Injection
(gatifloxacin in 5% dextrose) Injection

DRUG DESCRIPTION

TEQUIN® is available as TEQUIN (gatifloxacin) Tablets for oral administration and TEQUIN (gatifloxacin) Injection and TEQUIN (gatifloxacin in 5% dextrose) Injection for intravenous administration.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of TEQUIN (gatifloxacin removed from us market - may 2006) and other antibacterial drugs, TEQUIN (gatifloxacin removed from us market - may 2006) should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

TEQUIN contains gatifloxacin, a synthetic broad-spectrum 8-methoxyfluoroquinolone antibacterial agent for oral or intravenous administration. Chemically, gatifloxacin is (±)-1-cyclopropyl-6-fluoro-1, 4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid sesquihydrate.

The chemical structure is:

Its empirical formula is C19H22FN3O4·1.5 H2O and its molecular weight is 402.42. Gatifloxacin is a sesquihydrate crystalline powder and is white to pale yellow in color. It exists as a racemate, with no net optical rotation. The solubility of the compound is pH dependent. The maximum aqueous solubility (40-60 mg/mL) occurs at a pH range of 2 to 5.

TEQUIN (gatifloxacin removed from us market - may 2006) Tablets

TEQUIN (gatifloxacin removed from us market - may 2006) Tablets are available as 200-mg and 400-mg white, film-coated tablets and contain the following inactive ingredients: hypromellose, magnesium stearate, methylcellulose, microcrystalline cellulose, polyethylene glycol, polysorbate 80, simethicone, sodium starch glycolate, sorbic acid, and titanium dioxide.

TEQUIN (gatifloxacin removed from us market - may 2006) Injection for Intravenous Administration

TEQUIN (gatifloxacin removed from us market - may 2006) Injection is available in 40-mL (400-mg) single-use vials as a sterile, preservative-free aqueous solution of gatifloxacin with pH ranging from 3.5 to 5.5. TEQUIN (gatifloxacin in 5% dextrose) Injection is also available in ready-to-use 100-mL (200-mg) and 200-mL (400-mg) flexible bags as a sterile, preservative-free aqueous solution of gatifloxacin with pH ranging from 3.5 to 5.5. The appearance of the intravenous solution may range from light yellow to greenish-yellow in color. The color does not affect nor is it indicative of product stability.

The intravenous formulation contains dextrose, anhydrous, USP or dextrose, monohydrate, USP and Water for Injection, USP, and may contain hydrochloric acid and/or sodium hydroxide for pH adjustment.

Last reviewed on RxList: 1/13/2005
This monograph has been modified to include the generic and brand name in many instances.

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