Local irritation may be present after intramuscular injection. The injection should be deep, with care taken not to injure the sciatic nerve nor inject intravascularly.

Gastrointestinal:  anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis, and inflammatory lesions (with monilial overgrowth) in the anogenital region. These reactions have been caused by both the oral and parenteral administration of tetracyclines.

Skin:  maculopapular and erythematous rashes. Exfoliative dermatitis has been reported but is uncommon. Photosensitivity is discussed above. (See " WARNINGS ").

Renal toxicity:  Rise in BUN has been reported and is apparently dose related. (See " Warnings ").

Hypersensitivity reactions:  Urticaria, angioneurotic edema, anaphylaxis, anaphylactoid purpura, pericarditis, and exacerbation of systemic lupus erythematosus.

Bulging fontanels in infants and benign intracranial hypertension in adults have been reported in individuals receiving full therapeutic dosages. These conditions disappeared rapidly when the drug was discontinued.

Blood:  Hemolytic anemia, thrombocytopenia, neutropenia, and eosinophilia have been reported.

When given over prolonged periods, tetracyclines have been reported to produce brown-black microscopic discoloration of thyroid glands. No abnormalities of thyroid function studies are known to occur.

Read the Terramycin (oxytetracycline) Side Effects Center for a complete guide to possible side effects »

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Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.