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Tetanus Toxoid Adsorbed

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Tetanus Toxoid Adsorbed

Tetanus Toxoid Adsorbed USP

Tetanus Toxoid Adsorbed


Tetanus Toxoid Adsorbed USP, for intramuscular use, is a sterile suspension of alum-precipitated (aluminum potassium sulfate) toxoid in an isotonic sodium chloride solution containing sodium phosphate buffer to control pH. The vaccine, after shaking, is a turbid liquid, whitish-gray in color.

Clostridium tetani culture is grown in a peptone-based medium and detoxified with formaldehyde. The detoxified material is then purified by serial ammonium sulfate fractionation, followed by sterile filtration, and the toxoid is adsorbed to aluminum potassium sulfate (alum). The adsorbed toxoid is diluted with physiological saline solution (0.85%) and thimerosal (a mercury derivative) is added to a final concentration of 1:10,000.

Each 0.5 mL dose is formulated to contain 5 Lf (flocculation units) of tetanus toxoid and not more than 0.25 mg of aluminum. The residual formaldehyde content, by assay, is less than 0.02%. The tetanus toxoid induces at least 2 units of antitoxin per mL in the guinea pig potency test.

What are the possible side effects of tetanus toxoid vaccine (Tetanus Toxoid, Tetanus Toxoid Adsorbed)?

Getting tetanus is much riskier than getting the tetanus toxoid vaccine. However, a vaccine, like any medicine, is capable of causing serious problems, such as severe allergic reactions. The risk of tetanus toxoid vaccine causing serious harm, or death, is extremely small.

Seek emergency medical attention or contact your doctor immediately if any of the following rare but serious side effects from tetanus toxoid are experienced:

  • a serious allergic reaction including swelling of the lips, tongue, or face; difficulty breathing;...

Read All Potential Side Effects and See Pictures of Tetanus Toxoid Adsorbed »

Last reviewed on RxList: 1/13/2009
This monograph has been modified to include the generic and brand name in many instances.


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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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