"Dec. 18, 2012 -- People who can't get their high blood pressure down with drugs may be helped by a new procedure that deactivates overactive nerves in the kidneys, a small study shows.
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TEVETEN® is indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensives such as diuretics and calcium channel blockers.
DOSAGE AND ADMINISTRATION
The usual recommended starting dose of TEVETEN® is 600 mg once daily when used as monotherapy in patients who are not volume-depleted (see WARNINGS, Hypotension in Volume- and/or Salt-Depleted Patients). TEVETEN® can be administered once or twice daily with total daily doses ranging from 400 mg to 800 mg. There is limited experience with doses beyond 800 mg/day.
If the antihypertensive effect measured at trough using once-daily dosing is inadequate, a twice-a-day regimen at the same total daily dose or an increase in dose may give a more satisfactory response. Achievement of maximum blood pressure reduction in most patients may take 2 to 3 weeks.
TEVETEN® may be used in combination with other antihypertensive agents such as thiazide diuretics or calcium channel blockers if additional blood-pressure-lowering effect is required. Discontinuation of treatment with eprosartan does not lead to a rapid rebound increase in blood pressure.
Elderly, Hepatically Impaired or Renally Impaired Patients
No initial dosing adjustment is generally necessary for elderly or hepatically impaired patients or those with renal impairment. No initial dosing adjustment is generally necessary in patients with moderate and severe renal impairment, with maximum dose not exceeding 600 mg daily.
TEVETEN® may be taken with or without food.
TEVETEN® is available as aqueous film-coated tablets as follows:
400 mg pink, non-scored, oval tablets, debossed with "5044" on one side.
NDC 0074-3025-11 (bottles of 100)
600 mg white, non-scored, capsule-shaped tablets, debossed with "5046" on one side.
NDC 0074-3040-11 (bottles of 100)
Store at controlled room temperature 20 to 25°C (68 to 77°F) [see USP Controlled Room Temperature].
Abbott Laboratories North Chicago, IL 60064 U.S.A.
Last reviewed on RxList: 9/24/2012
This monograph has been modified to include the generic and brand name in many instances.
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