Teveten HCT (Eprosartan Mesylate Hydrochlorothiazide Tablets) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 27, 2012

Teveten HCT

Angiotensin Receptor Blockers (ARBs) »

What are angiotensin receptor blockers (ARBs) and how do they work?

The class of drugs called angiotensin receptor blockers (ARBs), as the class name suggests, are drugs that block the action of angiotensin. Specifically, ARBs prevent angiotensin II from binding to the angiotensin II receptor on blood vessels and other tissues.

Angiotensin II is a very potent chemical that causes the muscles surrounding blood vessels to contract, thereby narrowing the blood vessels. Narrowing of blood vessels increases the pressure within the blood vessels and may lead to high blood pressure (hypertension). Reducing the binding and activity of angiotensin II leads to widening (dilation) of blood vessels and reduces blood pressure. By lowering blood pressure against which the heart must pump, the amount of work that the heart must do is reduced. ACE inhibitors also reduce blood pressure in the kidneys, slowing the progression of kidney disease due to high b...

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Teveten HCT

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TEVETEN® HCT
(eprosartan mesylate/hydrochlorothiazide) 600/12.5 mg 600/25 mg

WARNING: FETAL TOXICITY

See full prescribing information for complete boxed warning.

When pregnancy is detected, discontinue TEVETEN HCT as soon as possible.
Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. See WARNINGS: Fetal Toxicity

DRUG DESCRIPTION

TEVETEN® HCT 600/12.5 mg and TEVETEN® HCT 600/25 mg (eprosartan mesylate-hydrochlorothiazide) combine an angiotensin II receptor (AT₁ subtype) antagonist and a diuretic, hydrochlorothiazide. TEVETEN® (eprosartan mesylate) is a non-biphenyl non-tetrazole angiotensin II receptor (AT₁) antagonist. A selective non-peptide molecule, TEVETEN® is chemically described as the monomethanesulfonate of (E)-2-butyl-1-(pcarboxybenzyl)-α-2-thienylmethylimidazole-5-acrylic acid. Its empirical formula is C₂₃H₂₄N₂O₄S•ECH₄O₃S and molecular weight is 520.625. Its structural formula is:

Eprosartan mesylate Structural Formula Illustration

Eprosartan mesylate is a white to off-white free-flowing crystalline powder that is insoluble in water, freely soluble in ethanol, and melts between 248°C and 250°C. Hydrochlorothiazide is 6-chloro-3,4-dihydro-2 H 1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. Its empirical formula is C₇H₈ClN₃O₄S₂ and its structural formula is:

Hydrochlorothiazide Structural Formula Illustration

Hydrochlorothiazide is a white, or practically white, crystalline powder with a molecular weight of 297.74, which is slightly soluble in water, but freely soluble in sodium hydroxide solution. TEVETEN® HCT is available for oral administration in film-coated, non-scored, capsule-shaped tablet combinations of eprosartan mesylate and hydrochlorothiazide. TEVETEN® HCT 600/12.5 mg contains 735.8 mg of eprosartan mesylate (equivalent to 600 mg eprosartan) and 12.5 mg hydrochlorothiazide in a butterscotch-colored tablet. TEVETEN® HCT 600/25 mg contains 735.8 mg of eprosartan mesylate (equivalent to 600 mg eprosartan) and 25 mg hydrochlorothiazide in a brick-red tablet. Inactive ingredients of both tablets: microcrystalline cellulose, lactose monohydrate, pregelatinized starch, crospovidone, magnesium stearate, and purified water. Ingredients of the OPADRY® 85F27320 butterscotch film coating: polyethylene glycol 3350, talc, polyvinyl alcohol, titanium dioxide, iron oxide black, and iron oxide yellow. Ingredients of the OPADRY® II 85F24297 pink film coating: polyethylene glycol 3350, titanium dioxide, talc, polyvinyl alcohol, iron oxide red, and iron oxide yellow.

What are the possible side effects of eprosartan (Teveten)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

In rare cases, eprosartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have muscle pain, tenderness, or weakness especially if you also have fever, nausea or vomiting, and dark colored urine.

Call your doctor at once if you have any of these other serious side effects, such...

Read All Potential Side Effects and See Pictures of Teveten HCT »

What are the precautions when taking eprosartan mesylate hydrochlorothiazide tablets (Teveten HCT)?

Before taking this medication, tell your doctor or pharmacist if you are allergic to eprosartan or hydrochlorothiazide; or to ACE inhibitors (e.g., captopril, lisinopril); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: an inability to make urine.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, severe loss of body fluids (dehydration through too much sweating/vomiting/diarrhea), mineral/electrolyte problems (e.g.,...

Read All Potential Precautions of Teveten HCT »

Last reviewed on RxList: 1/30/2012
This monograph has been modified to include the generic and brand name in many instances.