November 25, 2015
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"The cystic fibrosis (CF) drug Orkambi (Vertex Pharmaceuticals) has received a green light from the European Medicines Agency (EMA) Committee for Medicinal Products for Human Use (CHMP).

Orkambi is a fixed-dose oral combination "...




Symptoms of acute overdosage include nausea, weakness, dizziness and disturbances of electrolyte balance.The oral LD50 of the drug in the mouse and the rat is more than 25,000 mg/kg body weight.The minimum lethal dose (MLD) in humans has not been established.There is no specific antidote but gastric lavage is recommended, followed by supportive treatment. Where necessary, this may include intravenous dextrose-saline with potassium,administered with caution.


Anuria. Known hypersensitivity to chlorthalidone or other sulfonamide-derived drugs.

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 7/16/2008


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