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Thalitone

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Thalitone

Side Effects
Interactions

SIDE EFFECTS

The following adverse reactions have been observed, but there is not enough systematic collection of data to support an estimate of their frequency.

Gastrointestinal System Reactions: anorexia, gastric irritation, nausea, vomiting, cramping, diarrhea, constipation, jaundice (intrahepatic cholestatic jaundice), pancreatitis.

Central Nervous System Reactions: dizziness, vertigo, paresthesias, headache, xanthopsia.

Hematologic Reactions: leukopenia,agranulocytosis,thrombocytopenia, aplastic anemia.

Dermatologic-Hypersensitivity Reactions: purpura, photosensitivity, rash, urticaria, necrotizing angiitis (vasculitis) (cutaneous vasculitis), Lyell's syndrome (toxic epidermal necrolysis).

Cardiovascular Reaction: Orthostatic hypotension may occur and may be aggravated by alcohol,barbiturates or narcotics.

Other Adverse Reactions: hyperglycemia, glycosuria, hyperuricemia, muscle spasm,weakness,restlessness,impotence.

Whenever adverse reactions are moderate or severe, chlorthalidone dosage should be reduced or therapy withdrawn.

Read the Thalitone (chlorthalidone) Side Effects Center for a complete guide to possible side effects

DRUG INTERACTIONS

Chlorthalidone may add to or potentiate the action of other antihypertensive drugs.

Insulin requirements in diabetic patients may be increased, decreased or unchanged. Higher dosage of oral hypoglycemic agents may be required.

Chlorthalidone and related drugs may increase the responsiveness to tubocurarine.

Chlorthalidone and related drugs may decrease arterial responsiveness to norepinephrine. This diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use.

Lithium renal clearance is reduced by chlorthalidone,increasing the risk of lithium toxicity.

Drug/Laboratory Test Interactions

Chlorthalidone and related drugs may decrease serum PBI levels without signs of thyroid disturbance.

Read the Thalitone Drug Interactions Center for a complete guide to possible interactions

Last reviewed on RxList: 7/16/2008
This monograph has been modified to include the generic and brand name in many instances.

Side Effects
Interactions
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