"The cystic fibrosis (CF) drug Orkambi (Vertex Pharmaceuticals) has received a green light from the European Medicines Agency (EMA) Committee for Medicinal Products for Human Use (CHMP).
Orkambi is a fixed-dose oral combination "...
The following adverse reactions have been observed, but there is not enough systematic collection of data to support an estimate of their frequency.
Cardiovascular Reaction: Orthostatic hypotension may occur and may be aggravated by alcohol,barbiturates or narcotics.
Whenever adverse reactions are moderate or severe, chlorthalidone dosage should be reduced or therapy withdrawn.
Read the Thalitone (chlorthalidone) Side Effects Center for a complete guide to possible side effects
Chlorthalidone may add to or potentiate the action of other antihypertensive drugs.
Chlorthalidone and related drugs may increase the responsiveness to tubocurarine.
Drug/Laboratory Test Interactions
Read the Thalitone Drug Interactions Center for a complete guide to possible interactions
Last reviewed on RxList: 7/16/2008
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