"The U.S. Food and Drug Administration today expanded the approved uses of Abraxane (paclitaxel protein-bound particles for injectable suspension, albumin-bound) to treat patients with late-stage (metastatic) pancreatic cancer.
Thiotepa (thiotepa) For Injection USP
Thiotepa (thiotepa) for Injection USP is an ethylenimine-type compound. It is supplied as a non-pyrogenic, sterile Iyophilized powder for intravenous, intracavitary or intravesical administration, containing 15 mg of thiotepa (thiotepa injection) . Thiotepa (thiotepa injection) is a synthetic product with antitumor activity. The chemical name for thiotepa is Tris (1-aziridinyl) phosphine sulfide. Thiotepa (thiotepa injection) has the following structural formula:
Thiotepa (thiotepa injection) has the molecular formula C6H12N3PS, and a molecular weight of 189.22. When reconstituted with Sterile Water for Injection, the resulting solution has a pH of approximately 5.5 to 7.5. Thiotepa (thiotepa injection) is stable in alkaline medium and unstable in acid medium.
What are the possible side effects of thiotepa (Thioplex)?
If you experience any of the following serious side effects from thiotepa, seek emergency medical attention or contact your doctor immediately:
- an allergic reaction (including difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
- decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; or fever, chills, or signs of infection);
- tissue or vein reactions near the site of administration;
- liver damage (abdominal pain, yellowing of the skin or...
Last reviewed on RxList: 11/20/2008
This monograph has been modified to include the generic and brand name in many instances.
Additional Thiotepa Information
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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