Thiotepa (Thiotepa Injection) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 10, 2012

thiotepa

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Cancer is the uncontrolled growth of abnormal cells anywhere in a body. The abnormal cells are termed cancer cells, malignant cells, or tumor cells. Many cancers and the abnormal cells that compose the cancer tissue are further identified by the name of the tissue that the abnormal cells originated from (for example, breast cancer, lung cancer, colon cancer). Cancer is not confined to humans; animals and other living organisms can get cancer. Below is a schematic that shows normal cell division and how when a cell is damaged or altered without repair to its system, the cell usually dies. Also shown is what can occur when such damaged or unrepaired cells do not die and become cancer cells and proliferate with uncontrolled growth; a mass of cancer cells develop. Frequently, cancer cells can break away from this original mass of cells, travel through the blood and lymph systems, and lodge in other organs where they can again repeat the ...

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Thiotepa

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Thiotepa (thiotepa (thiotepa injection) injection) For Injection USP

DRUG DESCRIPTION

Thiotepa (thiotepa (thiotepa injection) injection) for Injection USP is an ethylenimine-type compound. It is supplied as a non-pyrogenic, sterile Iyophilized powder for intravenous, intracavitary or intravesical administration, containing 15 mg of thiotepa (thiotepa injection) . Thiotepa (thiotepa (thiotepa injection) injection) is a synthetic product with antitumor activity. The chemical name for thiotepa is Tris (1-aziridinyl) phosphine sulfide. Thiotepa (thiotepa (thiotepa injection) injection) has the following structural formula:

Thiotepa Structural Formula Illustration

Thiotepa (thiotepa (thiotepa injection) injection) has the molecular formula C₆H₁₂N₃PS, and a molecular weight of 189.22. When reconstituted with Sterile Water for Injection, the resulting solution has a pH of approximately 5.5 to 7.5. Thiotepa (thiotepa (thiotepa injection) injection) is stable in alkaline medium and unstable in acid medium.

What are the possible side effects of thiotepa (Thioplex)?

If you experience any of the following serious side effects from thiotepa, seek emergency medical attention or contact your doctor immediately:

an allergic reaction (including difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; or fever, chills, or signs of infection);
tissue or vein reactions near the site of administration;
liver...

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What are the precautions when taking thiotepa injection (Thiotepa)?

Before using thiotepa, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially: bone marrow problems (e.g., low white blood cell count/platelets from previous chemotherapy/radiation treatment), kidney disease, liver disease.

Wash your hands well to prevent the spread of infections. Do not have immunizations/vaccinations without the consent of your doctor, and avoid contact with people who have recently received oral polio vaccine or flu vaccine inhaled through the nose.

To lower your risk of...

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Last reviewed on RxList: 11/20/2008
This monograph has been modified to include the generic and brand name in many instances.