Hematopoietic toxicity can occur following overdose, manifested by a decrease in the white cell count and/or platelets. Red blood cell count is a less accurate indicator of thiotepa (thiotepa (thiotepa injection) injection) toxicity. Bleeding manifestations may develop. The patient may become more vulnerable to infection, and less able to combat such infection.

Dosages within and minimally above the recommended therapeutic doses have been associated with potentially life-threatening hematopoi-etic toxicity. Thiotepa (thiotepa (thiotepa injection) injection) has a toxic effect on the hematopoietic system that is dose related.

Thiotepa (thiotepa (thiotepa injection) injection) is dialyzable.

There is no known antidote for overdosage with thiotepa (thiotepa (thiotepa injection) injection) . Transfusions of whole blood or platelets have proven beneficial to the patient in combating hematopoietic toxicity.

Thiotepa (thiotepa (thiotepa injection) injection) is contraindicated in patients with a known hypersensitivity (allergy) to this preparation.

Therapy is probably contraindicated in cases of existing hepatic, renal, or bone-marrow damage. However, if the need outweighs the risk in such patients, thiotepa (thiotepa (thiotepa injection) injection) may be used in low dosage, and accompanied by hepatic, renal and hemopoietic function tests.

Last reviewed on RxList: 11/20/2008
This monograph has been modified to include the generic and brand name in many instances.