April 26, 2017
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Thiotepa Patient Information Including Side Effects

Brand Names: Thioplex

Generic Name: thiotepa (Pronunciation: THYE oh TEP a)

What is thiotepa (Thiotepa)?

Thiotepa is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Thiotepa is used to treat cancer of the breast, ovary, bladder, and others.

Thiotepa may also be used for purposes not listed in this medication guide.

What are the possible side effects of thiotepa (Thiotepa)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; wheezing, difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • fever, chills, body aches, flu symptoms, sores in your mouth and throat;
  • pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • bloody, black, or tarry stools;
  • cough up blood or vomit that looks like coffee grounds;
  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • painful or difficult urination;
  • urinating less than usual;
  • severe nausea or vomiting; or
  • pain, burning, irritation, or skin changes where the injection was given.

Less serious side effects may include:

  • headache, dizziness, feeling weak or tired;
  • blurred vision;
  • mild nausea, mild stomach pain, occasional vomiting;
  • eye redness, puffy eyelids;
  • temporary hair loss;
  • mild rash or itching;
  • mild pain where the medicine was injected;
  • skin discoloration; or
  • missed menstrual periods.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the Thiotepa (thiotepa injection) Side Effects Center for a complete guide to possible side effects

What is the most important information I should know about thiotepa (Thiotepa)?

Do not use thiotepa if you are pregnant. It could harm the unborn baby. Use birth control to prevent pregnancy while you are receiving thiotepa, whether you are a man or a woman. Thiotepa use by either parent may cause birth defects.

Thiotepa can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Avoid being near people who are sick or have infections. Avoid activities that may increase your risk of bleeding injury. Tell your doctor at once if you develop signs of infection.

You should not receive thiotepa if you are allergic to it.

Before you receive thiotepa, tell your doctor if you have kidney disease, liver disease, bone marrow suppression, or if you have recently received other cancer treatments (including chemotherapy or radiation).

Do not receive a "live" vaccine while using thiotepa. The vaccine may not work as well during this time, and may not fully protect you from disease. Live vaccines include measles, mumps, rubella (MMR), Bacillus Calmette-Guérin (BCG), oral polio, rotavirus, smallpox, typhoid, yellow fever, varicella (chickenpox), H1N1 influenza, and nasal flu vaccine.

Call your doctor at once if you have a serious side effect, such as fever, chills, flu symptoms, mouth sores, pale skin, easy bruising or bleeding, bloody or tarry stools, coughing up blood, painful urination, urinating less than usual, severe nausea or vomiting, upper stomach pain, yellowing of your skin or eyes, dark urine, feeling light-headed, or skin changes where the injection was given.

Side Effects Centers

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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