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thiotepa Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Thiotepa injection is a cancer (antineoplastic) medication used in the treatment of cancers of the breast, ovary, bladder, and others. Common side effects of Thiotepa include:
- stomach pain
- loss of appetite
- redness or inflammation of the eyes
- puffy eyelids
- blurred vision
- temporary hair loss
- skin discoloration
- rash or itching
- injection site pain, or
- decreased menstruation/missed menstrual periods in women and decreased sperm production in men.
Dosage of Thiotepa is individualized. Consult your doctor. Thiotepa may interact with "live" vaccines and other drugs. Tell your doctor all medications and supplements you use and all vaccines you have recently received. Thiotepa is not recommended for use during pregnancy. It is harmful to a fetus. Men and women should talk to their doctors about using birth control during treatment with thiotepa. It is unknown if thiotepa passes into breast milk. Consult your doctor before breastfeeding.
Our Thiotepa injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
thiotepa in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; wheezing, difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- fever, chills, body aches, flu symptoms, sores in your mouth and throat;
- pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
- easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
- bloody, black, or tarry stools;
- cough up blood or vomit that looks like coffee grounds;
- nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
- painful or difficult urination;
- urinating less than usual;
- severe nausea or vomiting; or
- pain, burning, irritation, or skin changes where the injection was given.
Less serious side effects may include:
- headache, dizziness, feeling weak or tired;
- blurred vision;
- mild nausea, mild stomach pain, occasional vomiting;
- eye redness, puffy eyelids;
- temporary hair loss;
- mild rash or itching;
- mild pain where the medicine was injected;
- skin discoloration; or
- missed menstrual periods.
Read the entire detailed patient monograph for thiotepa (Thiotepa Injection)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
thiotepa FDA Prescribing Information: Side Effects
Renal: Dysuria, urinary retention. There have been rare reports of chemical cystitis or hemorrhagic cystitis following intravesical, but not parenteral administration of thiotepa (thiotepa (thiotepa injection) injection) .
Respiratory: Prolonged apnea has been reported when succinylcholine was administered prior to surgery, following combined use of thiotepa (thiotepa (thiotepa injection) injection) and other anticancer agents. It was theorized that this was caused by decrease of pseudocholinesterase activity caused by the anticancer drugs.
Neurologic: Dizziness, headache, blurred vision.
Special Senses: Conjunctivitis.
Reproductive: Amenorrhea, interference with spermatogenesis.
Read the entire FDA prescribing information for thiotepa (Thiotepa Injection)
Additional Thiotepa Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Get the latest treatment options.