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Thrombate Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 4/12/2016

Thrombate III (Antithrombin III [Human]) is a form of protein found in the blood used to treat patients with hereditary antithrombin III deficiency in connection with surgical or obstetrical procedures or when they suffer from thromboembolism. Common side effects of Thrombate III include:

  • dizziness
  • chest tightness or pain
  • nausea
  • foul or unusual taste in mouth
  • chills
  • cramps
  • shortness of breath
  • film over eye
  • lightheadedness
  • bowel fullness
  • hives
  • fever
  • oozing and
  • blood blister formation

Dosage should be determined on an individual basis based on the pre-therapy plasma antithrombin III (AT-III) level, in order to increase plasma AT-III levels to the level found in normal human plasma (100%). Thrombate III may interact with heparin. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before starting treatment with Thrombate III. Consult your doctor before breastfeeding.

Our Thrombate III (Antithrombin III [Human]) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Thrombate FDA Prescribing Information: Side Effects
(Adverse Reactions)


In clinical studies involving THROMBATE (antithrombin) III, adverse reactions were reported in association with 17 of the 340 infusions during the clinical studies. Included were dizziness (7), chest tightness (3), nausea (3), foul taste in mouth (3), chills (2), cramps (2), shortness of breath (1), chest pain (1), film over eye (1), light-headedness (1), bowel fullness (1), hives (1), fever (1), and oozing and hematoma formation (1). If adverse reactions are experienced, the infusion rate should be decreased, or if indicated, the infusion should be interrupted until symptoms abate.

Read the entire FDA prescribing information for Thrombate (Antithrombin)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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