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Thrombin Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 3/25/2016

Thrombin-JMI (thrombin topical bovine origin) is an anticoagulant used to help stop oozing blood and minor bleeding from capillaries. Common side effects of Thrombin-JMI include:

  • allergic reactions in people known to be sensitive to bovine materials
  • bleeding
  • low levels of iron in the blood (anemia)
  • post-operative wound infection
  • blood clots that break loose (thromboembolic events)
  • low blood pressure (hypotension)
  • fever
  • fast heart rate, and
  • low levels of platelets in the blood.

Where bleeding is profuse, the dose of Thrombin-JMI is usually concentrations of 1,000 International Units per mL. For general use in plastic surgery, dental extractions, skin grafting, etc. solutions containing approximately 100 International Units/mL are frequently used. Thrombin may interact with other drugs. Tell your doctor all medications and supplements you use. During pregnancy, Thrombin-JMI should be used only if prescribed. Consult your doctor before breastfeeding.

Our Thrombin-JMI (thrombin topical bovine origin) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Thrombin FDA Prescribing Information: Side Effects
(Adverse Reactions)


Allergic reactions may be encountered in persons known to be sensitive to bovine materials. Inhibitory antibodies which interfere with hemostasis may develop in a small percentage of patients. See WARNINGS.

Read the entire FDA prescribing information for Thrombin (Thrombin Topical Bovine Origin)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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