July 29, 2016
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Thrombocytopenia (Low Platelet Count) (cont.)

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Decreased platelet production

Decreased platelet production is usually related to a bone marrow problem. In some of these conditions, red blood cell and white blood cell productions may also be affected.

  • Viral infections affecting the marrow for example
  • Aplastic anemia is a general term used when the bone marrow fails to produce any blood cells (red cells, white cells, and platelets), also called pancytopenia. This can be caused by some viral infections (parvovirus or HIV), medications (gold, chloramphenicol, phenytoin [Dilantin], valproate [Depakote]), or radiation, or rarely, it can be congenital (Fanconi's anemia).
  • Chemotherapy drugs frequently cause bone marrow suppression resulting in thrombocytopenia.
  • Some drugs other than chemotherapy can suppress platelet production, such as thiazide diuretics.
  • Cancers of the bone marrow and blood (leukemia) or cancers of the lym ph nodes (lymphoma) can cause various degrees of thrombocytopenia.
  • Cancers from other organs can sometimes infiltrate (invade) the bone marrow and result in impaired production of platelets.
  • Long term alcohol can cause direct toxicity of the bone marrow.
  • Deficiency of vitamin B12 and folic acid can result in low platelet production by the bone marrow.
Medically Reviewed by a Doctor on 7/1/2016

Source: MedicineNet.com
http://www.medicinenet.com/thrombocytopenia_low_platelet_count/article.htm

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