" Type 2 diabetes usually begins with insulin resistance, a condition in which the body produces insulin but isn't able to use it effectively. As a result, glucose builds up in blood and may ultimately damage nerves, blood vessels, and other b"...
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Chemically, Thyrel® TRH (protirelin) is identified as 5-oxo-L-prolyl-L-histidyl-L-proline amide. It is a synthetic tripeptide that is believed to be structurally identical to the naturally-occurring thyrotropin-releasing hormone produced by the hypothalamus. The CAS Registry Number is 24305-27-9. The structual formula is:
Thyrel TRH (protirelin) is supplied as 1 mL ampuls. Each ampul contains 500 µg protirelin in a sterile nonpyrogenic isotonic saline solution having a pH of approximately 6.5. In addition, each ampul contains sodium chloride 9.0 mg, Water for Injection, hydrochloric acid and sodium hydroxide as needed to adjust pH. Thyrel TRH (protirelin) is intended for intravenous administration.
Last reviewed on RxList: 1/18/2005
This monograph has been modified to include the generic and brand name in many instances.
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